Table 1 The role of circRNAs in hematological tumors
Circ based ID / Common Name | Hematological malignancies | Expression pattern | Target miRNA/Target gene | Function | Ref. |
|---|---|---|---|---|---|
circ-0000190 | MM | ↓ | miR-767-5p/MAPK4 | Biomarkers of risk stratification and prognosis | [54] |
circRPL15 | CLL | ↑ | miR-146b-3p/RAF1 | Biomarkers of CLL prognosis | [76] |
circ-0004277 | AML | ↓ | WDR37 | Biomarkers of risk stratification and therapeutic response | [52] |
circDLEU2 | AML | ↑ | miRNA-496/PRKACB | Promoting cell proliferation and inhibiting apoptosis | [77] |
circ-0004136 | AML | ↑ | miRNA-142 | Promoting cell proliferation and inhibiting apoptosis | [60] |
circ-0132266 | CLL | ↓ | miR-337-3p/PML | Promoting cell proliferation and inhibiting apoptosis | [78] |
circCBFB | CLL | ↑ | miR-607/FZD3/ Wnt/b-catenin pathway | Promoting cell proliferation, cell cycle, and inhibiting apoptosis | [70] |
circPVT1 | ALL | ↑ | miRNA-let-7 and miR-125/c-Myc/Bcl-2 | Promoting cell proliferation, cell cycle and inhibiting apoptosis | |
circADD2 | ALL | ↓ | miR-149-5p/AKT2 | Promoting apoptosis and inhibiting cell proliferation | [81] |
circHIPK3 | CML | ↑ | miR-124 | Promoting cell proliferation | [82] |
Circ-0009910 | CML | ↑ | miR-34a-5p/ULK1 | Promoting cell proliferation and inhibiting apoptosis, increasing chemoresistance of imatinib | |
circCDYL | MM | ↑ | miR-1180/YAP | Promoting cell proliferation and inhibiting apoptosis | [65] |
circ-0069767 | MM | ↑ | miR-636/K-RAS | Inhibiting cell proliferation, migration and invasion and promoting cell apoptosis | [72] |
circOTUD7A | DLBLL | ↑ | miR-431-5p/FOXP1 | Promoting cell proliferation and migration, inhibiting apoptosis | [83] |
circ-0127621 | DLBLL | ↓ | miR-888/APC/Wnt/β-catenin | Inhibiting cell proliferation | [84] |