Skip to main content

Table 3 Involvement of inflammasomes in TIME

From: The role of pyroptosis in modulating the tumor immune microenvironment

Inflammasome Role in regulating immune cells Targeted therapy
NLRP3 TAM (↑), MDSC (↑), Treg (↑)
CD8+ T cells (↓), NK cells (↓)
P2X7R antagonist
Thalidomide
Pralnacasan
Ac-YVAD-CHO
MCC950
Glyburide
Terpenoids
NLRC4 TAM (↑), CD8+ T cells (↑)
CD4+ T cells (↑), CD11b+ cells (↑)
NLRP1 CD8+ T cells (↓), NK cells (↓)
Th1 cells (↑)
AIM2 Treg (↑)
CD4+ effector T cells (↓), DC (↓)
  1. Note: ↑, the function of cells is enhanced; ↓, the function of cells is inhibited