Skip to main content

Table 3 Involvement of inflammasomes in TIME

From: The role of pyroptosis in modulating the tumor immune microenvironment

Inflammasome

Role in regulating immune cells

Targeted therapy

NLRP3

TAM (↑), MDSC (↑), Treg (↑)

CD8+ T cells (↓), NK cells (↓)

P2X7R antagonist

Thalidomide

Pralnacasan

Ac-YVAD-CHO

MCC950

Glyburide

Terpenoids

NLRC4

TAM (↑), CD8+ T cells (↑)

CD4+ T cells (↑), CD11b+ cells (↑)

NLRP1

CD8+ T cells (↓), NK cells (↓)

Th1 cells (↑)

AIM2

Treg (↑)

CD4+ effector T cells (↓), DC (↓)

  1. Note: ↑, the function of cells is enhanced; ↓, the function of cells is inhibited