From: The role of pyroptosis in modulating the tumor immune microenvironment
Inflammasome | Role in regulating immune cells | Targeted therapy |
---|---|---|
NLRP3 | TAM (↑), MDSC (↑), Treg (↑) CD8+ T cells (↓), NK cells (↓) | P2X7R antagonist Thalidomide Pralnacasan Ac-YVAD-CHO MCC950 Glyburide Terpenoids |
NLRC4 | TAM (↑), CD8+ T cells (↑) CD4+ T cells (↑), CD11b+ cells (↑) | |
NLRP1 | CD8+ T cells (↓), NK cells (↓) Th1 cells (↑) | |
AIM2 | Treg (↑) CD4+ effector T cells (↓), DC (↓) |