Table 2 Induction and cleavage of gasdermin family
From: The role of pyroptosis in modulating the tumor immune microenvironment
Gasdermin | Induced by | Cleaved by |
|---|---|---|
GSDMA | Group A Streptococcus [28] | Streptococcal pyrogenic exotoxin B [28] |
GSDMB | Viruses, allergens [29] IFN-γ [30] | Caspase-1 [31] Caspase-3/6/7 [29] Granzyme A [30] |
GSDMC | TNF-α [32] | Caspase-8 [32] |
GSDMD | Pathogens, injury, LPS | Caspase-1/4/5/11 |
GSDME | Doxorubicin, Cisplatin [25] Paclitaxel [33] Metformin [26] | Caspase-3/ 7[25] Granzyme B [34] |