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Table 2 Induction and cleavage of gasdermin family

From: The role of pyroptosis in modulating the tumor immune microenvironment

Gasdermin Induced by Cleaved by
GSDMA Group A Streptococcus [28] Streptococcal pyrogenic exotoxin B [28]
GSDMB Viruses, allergens [29]
IFN-γ [30]
Caspase-1 [31]
Caspase-3/6/7 [29]
Granzyme A [30]
GSDMC TNF-α [32] Caspase-8 [32]
GSDMD Pathogens, injury, LPS Caspase-1/4/5/11
GSDME Doxorubicin, Cisplatin [25]
Paclitaxel [33]
Metformin [26]
Caspase-3/ 7[25]
Granzyme B [34]