Table 1 The cellular components of the TIME in pancreatic cancer
From: The role of pyroptosis in modulating the tumor immune microenvironment
Cells | Cell-derived cytokines | Function |
|---|---|---|
Cancer cells | CCL-2, TGF-β, ICAM-1, GM-CSF, G-CSF, IL-10, IL-6, IL-1β | TAM (↑), MDSC (↑), PSC (↑), Treg (↑) CD8+T cells (↓), NK cells (↓) |
aPSC/CAF | CCL3, CCL6, IL-6, CXCL1, CXCL12 | Cancer cells (↑), TAM (↑), MDSC (↑) NK cells (↓), CD8 + T cells (↓), DC (↓) |
TAM | TGF-α, TGF-β, IL-10, IL-6, Arg-1 | Cancer cells (↑), Treg (↑), Th17 (↑) CD8+T cells (↓), NK cells (↓) |
MDSC | Arg-1, NO, IL-6 | Cancer cells (↑) CD8+T cells (↓), NK cells (↓) |
DC | IL-23, TGF-β | Th17 (↑) CD8+T cells (↓) |
Treg | TGF-β, IL-10 | PSC (↑) CD8+T cells (↓), NK cells (↓) |