Fig. 1
From: The role of pyroptosis in modulating the tumor immune microenvironment
The tumor immune microenvironment in pancreatic cancer. Pancreatic cancer is focused as an example to describe the TIME. Tumor cells, immune cells, and stromal cells interacting with each other via cytokines constitute a “cold” tumor with abundant extracellular matrix. aPSC, activated pancreatic stellate cells; DC, dendritic cells; MDSC, myeloid-derived suppressor cells; NK cells, natural killer cells; TAM, M2 tumor-associated macrophages; Th17, helper T cells 17; Treg, regulatory T cells