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Table 3 Overview of the 10 miR-1248 validated target genes included in the TSGene 2.0 database

From: MiR-1248: a new prognostic biomarker able to identify supratentorial hemispheric pediatric low-grade gliomas patients associated with progression

Official symbol Official full name Sequence accession ID Function
ANAPC1 Anaphase promoting complex subunit 1 NM_022662.4 ANAPC1 is a component of the anaphase-promoting complex, an E3 ubiquitin ligase complex that controls progression through the metaphase to anaphase of the cell cycle
CDKN1A Cyclin-dependent Kinase Inhibitor 1A NM_000389.4 P21 acts as a regulator of cell cycle progression at G1 in a p53-dependent and independent way. P21 plays regulatory roles in S phase DNA replication and DNA damage repair
FRK Fyn-related SRC Family Tyrosine kinase NM_002031.2 FRK suppresses cell growth and promotes PTEN protein stability. FRK may function as a tumour suppressor protein
HIVEP3 HIVEP zinc-finger 3 NM_001127714.3 HIVEP3 is a transcription factor that inhibits TNF-α induced NF-κB activation. HIVEP3 may interacts with TRAF proteins inhibiting the c-Jun/JNK signalling pathway
MTAP S-methyl-5'-thioadenosine phosphorylase NM_002451.3 MTAP is an enzyme involved in polyamine metabolism and its down-regulation and/or deletion has been described in many cancers
NOTCH2 Notch receptor 2 NM_001200001.2 NOTCH2 belongs to an evolutionarily conserved intercellular signalling pathway with roles in cell fate decisions, such proliferation, differentiation and apoptosis
PRKCB Protein kinase C beta NM_002738.7 PRKCB is a serine/threonine protein kinase involved in several cellular processes, such as oxidative stress induced apoptosis, insulin signalling and glucose transport regulation
SH2B3 SH2B adaptor protein 3 NM_001291424.1 SH2B3 is a negative regulator of cytokine signalling with critical roles in hematopoiesis
SPOP Speckle-type POZ protein NM_001007226.1 SPOP is a member of the E3 ubiquitin-protein ligase complex and mediates the ubiquitination and subsequent degradation of target proteins
VHL von Hippel-Lindau disease tumor suppressor NM_000551.3 VHL is a member of a protein complex with ubiquitin ligase E3 activity, being involved in the ubiquitination and degradation of hypoxia-inducible factors