Table 2 Function of circRNAs in ESCC

circ-ITCH

↓

Inhibited proliferation

miR-7, miR-17, miR-214

ITCH

[54]

circCNTNAP3

↓

Inhibited proliferation and increased apoptosis

miR-513a-5p

TP53

[57]

circ- Foxo3

↓

Inhibited proliferation and accelerated cell apoptosis

miR-23a

PTEN

[55]

circLARP4

↓

Inhibited proliferation and accelerated cell apoptosis

miR-1323

PTEN

[56]

circVRK1

↓

Inhibited proliferation, migration, enhanced the sensitivity of ESCC cells to radiotherapy

miR-624-3p

PTEN

[59]

circ FAT1

↓

Inhibited migration and invasion

/

/

[72]

circ0071662

↓

/

/

/

[73]

circ-SMAD7

↓

Inhibited proliferation and migration

/

/

[74]

circ-DOCK5

↓

Inhibited migration and invasion

miR-627-3p

TGFB2

[62]

circPSMC3

↓

Increased the sensitivity of ESCC cells to n

miR-10a-5p

PTEN

[75]

cDOPEY2

↓

Inhibited cisplatin resistance

/

CPEB4/TRIM25

[76]

circIMMP2L

↑

Promoted proliferation, migration and invasion

/

CtBP1

[77]

circ_0014879

↑

Promoted proliferation, migration, invasion and radiosensitivity

miR-519-3p

CDC25A

[78]

circAGFG1

↑

Promoted proliferation, migration and invasion

miR-4306

MAPRE2

[79]

circ_0006168

↑

Promoted proliferation, migration, invasion and Taxol resistance

miR-194-5p1

JMJD1C

[80]

↑

Promoted proliferation, migration and invasion

miR-516b-5p

XBP1

[81]

↑

Promoted proliferation, migration and invasion

miR-384

RBBP7

[82]

↑

Promoted proliferation, migration and invasion

miR-100

mTOR

[83]

↑

Promoted proliferation and inhibited apoptosis

miR-384

FN1

[84]

circ_0072088

↑

Promoted proliferation, migration and invasion

miR-377

VEGF

[85]

circ_0004771

↑

Promoted proliferation, migration and invasion

miR-339-5p

CDC25A

[86]

↑

Promoted proliferation, migration and invasion

miR-595

SEMA4D

[87]

circ0120816

↑

Promoted proliferation and inhibited apoptosis

miR-1305

TXNRD1

[67]

circ-ABCB10

↑

Promoted proliferation and invasion

miR-670-3p

/

[88]

circ-DLG1

↑

Promoted proliferation

/

/

[89]

circGSK3β

↑

Promoted migration

/

GSK3β

[90]

circRIMS

↑

Promoted proliferation

/

miR-613

[53]

circRNA_2646

↑

Promoted proliferation and migration

miR-124

PLP2

[91]

circRNA_141539

↑

Promoted proliferation and invasion

miR-4469

CDK3

[92]

circ- TTC17

↑

Promoted proliferation and migration

/

/

[93]

circ_0014715

↑

Promoted proliferation and migration

/

/

[94]

circLPAR3

↑

Promoted proliferation, migration and invasion

miR-375/miR-433

HMGB1

[95]

↑

Promoted migration

miR-198

MET

[58]

circ-LRP6

↑

Promoted proliferation

miR-182

Myc

[96]

circNELL2

↑

Promoted proliferation

miR-127-5p

CDC6

[52]

circ_0087378

↑

Promoted proliferation, migration and invasion

miR-140-3p

NRIP1

[64]

↑

Promoted proliferation, migration and invasion

miR-140-3p

E2F3

[63]

circ-PRKCI

↑

Promoted proliferation and migration

miR-3680-3p

AKT3

[61]

ciRS-7

↑

Promoted proliferation, migration and invasion

miR-876-5p

MAGE-A

[97]

↑

Inhibited autophagy

miR‐1299

EGFR

[98]

↑

Promoted migration and invasion

miR-7

KLF4

[99]

↑

Promoted proliferation and migration

miR-7

HOXB13

[100]

circPDE3B

↑

Promoted proliferation, migration and invasion

miR-4766-5p

LAMA1

[101]

circ_0000654

↑

Promoted proliferation and migration

miR-149-5p

IL-6

[102]

circ_0000700

↑

Promoted proliferation and migration

miR-1229

/

[103]

circ-ZDHHC5

↑

Promoted proliferation, migration and invasion

miR-217

ZEB1

[104]

circRNA_100876

↑

Promoted proliferation, migration, invasion and inhibited apoptosis

/

/

[66]

circ_0012563

↑

Promoted migration and invasion

/

XRCC1

[105]

circR_100873

↑

Increased lymphatic metastases

/

/

[106]

circRNA6448-14

↑

Promoted proliferation, migration, invasion, and inhibited apoptosis

miR-455-3p

/

[107]

circ-0048117

↑

Promoted migration and invasion

miR-140

TLR4

[108]

circ_0003340

↑

Promoted proliferation, migration and invasion

miR-615-5p

PDX1

[51]

↑

Promoted proliferation and inhibited cell apoptosis

miR-564

TPX2

[109]

circUBAP2

↑

Promoted proliferation, migration and invasion

miR-422a

Rab10

[110]

circ_0000337

↑

Promoted proliferation, migration and invasion

miR-670-5p

/

[111]

↑

Promoted CDDP resistance

miR-377-3p

JAK2

[112]

circGOT1

↑

Promoted proliferation, migration, aerobic glycolysis, and cisplatin resistance

miR-606

GOT1

[113]

circ_0006948

↑

Promoted proliferation, migration and invasion

miR-3612

LASP1

[114]

↑

Promoted proliferation, migration and invasion

miR-490-3p

HMGA2

[115]

circ_0023984

↑

Promoted proliferation, migration and invasion

miR-433-3p

REV3L

[116]

circDUSP16

↑

Contributed to hypoxia-stimulated ESCC cell progression

miR-497-5p

TKTL1

[117]

circRNA_100367

↑

Promoted radioresistant

miR-217

Wnt3

[118]

circ_0001093

↑

Promoted glutamine metabolism

miR-579-3p

glutaminase (GLS)

[119]

circCPSF6

↑

Promoted proliferation and inhibited cell apoptosis

/

CPSF6

[120]

circ_0007142

↑

Enhanced DDP-resistant

miR-494-3p

LASP1

[121]

circ_0003340

↑

Enhanced ESCC progression

miR-940

PRKAA1

[122]

circ-ATIC

↑

Enhanced ESCC progression

miR-326

ID1

[123]

circ_0000277

↑

Enhanced DDP-resistant

miR-873-5p

SOX4

[124]

circPUM1

↑

Regulated the mitochondrial oxidative phosphorylation

/

UQCRC2

[71]

circPVT1

↑

Inhibited 5-Fu sensitivity

miR-30a-5p

FZD3

[70]