Name | Expression | Function | Sponge miRNAs | Target genes | Refs | |
---|---|---|---|---|---|---|
circ-ITCH | ↓ | Inhibited proliferation | miR-7, miR-17, miR-214 | ITCH | [54] | |
circCNTNAP3 | ↓ | Inhibited proliferation and increased apoptosis | miR-513a-5p | TP53 | [57] | |
circ- Foxo3 | ↓ | Inhibited proliferation and accelerated cell apoptosis | miR-23a | PTEN | [55] | |
circLARP4 | ↓ | Inhibited proliferation and accelerated cell apoptosis | miR-1323 | PTEN | [56] | |
circVRK1 | ↓ | Inhibited proliferation, migration, enhanced the sensitivity of ESCC cells to radiotherapy | miR-624-3p | PTEN | [59] | |
circ FAT1 | ↓ | Inhibited migration and invasion | / | / | [72] | |
circ0071662 | ↓ | / | / | / | [73] | |
circ-SMAD7 | ↓ | Inhibited proliferation and migration | / | / | [74] | |
circ-DOCK5 | ↓ | Inhibited migration and invasion | miR-627-3p | TGFB2 | [62] | |
circPSMC3 | ↓ | Increased the sensitivity of ESCC cells to n | miR-10a-5p | PTEN | [75] | |
cDOPEY2 | ↓ | Inhibited cisplatin resistance | / | CPEB4/TRIM25 | [76] | |
circIMMP2L | ↑ | Promoted proliferation, migration and invasion | / | CtBP1 | [77] | |
circ_0014879 | ↑ | Promoted proliferation, migration, invasion and radiosensitivity | miR-519-3p | CDC25A | [78] | |
circAGFG1 | ↑ | Promoted proliferation, migration and invasion | miR-4306 | MAPRE2 | [79] | |
circ_0006168 | ↑ | Promoted proliferation, migration, invasion and Taxol resistance | miR-194-5p1 | JMJD1C | [80] | |
↑ | Promoted proliferation, migration and invasion | miR-516b-5p | XBP1 | [81] | ||
↑ | Promoted proliferation, migration and invasion | miR-384 | RBBP7 | [82] | ||
↑ | Promoted proliferation, migration and invasion | miR-100 | mTOR | [83] | ||
↑ | Promoted proliferation and inhibited apoptosis | miR-384 | FN1 | [84] | ||
circ_0072088 | ↑ | Promoted proliferation, migration and invasion | miR-377 | VEGF | [85] | |
circ_0004771 | ↑ | Promoted proliferation, migration and invasion | miR-339-5p | CDC25A | [86] | |
↑ | Promoted proliferation, migration and invasion | miR-595 | SEMA4D | [87] | ||
circ0120816 | ↑ | Promoted proliferation and inhibited apoptosis | miR-1305 | TXNRD1 | [67] | |
circ-ABCB10 | ↑ | Promoted proliferation and invasion | miR-670-3p | / | [88] | |
circ-DLG1 | ↑ | Promoted proliferation | / | / | [89] | |
circGSK3β | ↑ | Promoted migration | / | GSK3β | [90] | |
circRIMS | ↑ | Promoted proliferation | / | miR-613 | [53] | |
circRNA_2646 | ↑ | Promoted proliferation and migration | miR-124 | PLP2 | [91] | |
circRNA_141539 | ↑ | Promoted proliferation and invasion | miR-4469 | CDK3 | [92] | |
circ- TTC17 | ↑ | Promoted proliferation and migration | / | / | [93] | |
circ_0014715 | ↑ | Promoted proliferation and migration | / | / | [94] | |
circLPAR3 | ↑ | Promoted proliferation, migration and invasion | miR-375/miR-433 | HMGB1 | [95] | |
↑ | Promoted migration | miR-198 | MET | [58] | ||
circ-LRP6 | ↑ | Promoted proliferation | miR-182 | Myc | [96] | |
circNELL2 | ↑ | Promoted proliferation | miR-127-5p | CDC6 | [52] | |
circ_0087378 | ↑ | Promoted proliferation, migration and invasion | miR-140-3p | NRIP1 | [64] | |
↑ | Promoted proliferation, migration and invasion | miR-140-3p | E2F3 | [63] | ||
circ-PRKCI | ↑ | Promoted proliferation and migration | miR-3680-3p | AKT3 | [61] | |
ciRS-7 | ↑ | Promoted proliferation, migration and invasion | miR-876-5p | MAGE-A | [97] | |
↑ | Inhibited autophagy | miR‐1299 | EGFR | [98] | ||
↑ | Promoted migration and invasion | miR-7 | KLF4 | [99] | ||
↑ | Promoted proliferation and migration | miR-7 | HOXB13 | [100] | ||
circPDE3B | ↑ | Promoted proliferation, migration and invasion | miR-4766-5p | LAMA1 | [101] | |
circ_0000654 | ↑ | Promoted proliferation and migration | miR-149-5p | IL-6 | [102] | |
circ_0000700 | ↑ | Promoted proliferation and migration | miR-1229 | / | [103] | |
circ-ZDHHC5 | ↑ | Promoted proliferation, migration and invasion | miR-217 | ZEB1 | [104] | |
circRNA_100876 | ↑ | Promoted proliferation, migration, invasion and inhibited apoptosis | / | / | [66] | |
circ_0012563 | ↑ | Promoted migration and invasion | / | XRCC1 | [105] | |
circR_100873 | ↑ | Increased lymphatic metastases | / | / | [106] | |
circRNA6448-14 | ↑ | Promoted proliferation, migration, invasion, and inhibited apoptosis | miR-455-3p | / | [107] | |
circ-0048117 | ↑ | Promoted migration and invasion | miR-140 | TLR4 | [108] | |
circ_0003340 | ↑ | Promoted proliferation, migration and invasion | miR-615-5p | PDX1 | [51] | |
↑ | Promoted proliferation and inhibited cell apoptosis | miR-564 | TPX2 | [109] | ||
circUBAP2 | ↑ | Promoted proliferation, migration and invasion | miR-422a | Rab10 | [110] | |
circ_0000337 | ↑ | Promoted proliferation, migration and invasion | miR-670-5p | / | [111] | |
↑ | Promoted CDDP resistance | miR-377-3p | JAK2 | [112] | ||
circGOT1 | ↑ | Promoted proliferation, migration, aerobic glycolysis, and cisplatin resistance | miR-606 | GOT1 | [113] | |
circ_0006948 | ↑ | Promoted proliferation, migration and invasion | miR-3612 | LASP1 | [114] | |
↑ | Promoted proliferation, migration and invasion | miR-490-3p | HMGA2 | [115] | ||
circ_0023984 | ↑ | Promoted proliferation, migration and invasion | miR-433-3p | REV3L | [116] | |
circDUSP16 | ↑ | Contributed to hypoxia-stimulated ESCC cell progression | miR-497-5p | TKTL1 | [117] | |
circRNA_100367 | ↑ | Promoted radioresistant | miR-217 | Wnt3 | [118] | |
circ_0001093 | ↑ | Promoted glutamine metabolism | miR-579-3p | glutaminase (GLS) | [119] | |
circCPSF6 | ↑ | Promoted proliferation and inhibited cell apoptosis | / | CPSF6 | [120] | |
circ_0007142 | ↑ | Enhanced DDP-resistant | miR-494-3p | LASP1 | [121] | |
circ_0003340 | ↑ | Enhanced ESCC progression | miR-940 | PRKAA1 | [122] | |
circ-ATIC | ↑ | Enhanced ESCC progression | miR-326 | ID1 | [123] | |
circ_0000277 | ↑ | Enhanced DDP-resistant | miR-873-5p | SOX4 | [124] | |
circPUM1 | ↑ | Regulated the mitochondrial oxidative phosphorylation | / | UQCRC2 | [71] | |
circPVT1 | ↑ | Inhibited 5-Fu sensitivity | miR-30a-5p | FZD3 | [70] |