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Fig. 1 | Biomarker Research

Fig. 1

From: Current advances and future perspectives on the functional roles and clinical implications of circular RNAs in esophageal squamous cell carcinoma: more influential than expected

Fig. 1

Biogenesis of circRNAs. A lariat-driven circularization: the folding of pre-mRNA caused it to form lariat structure which are generated from the link of 5’ splice acceptor and 3’ splice donor. Furthermore, the lariat structure conduct internal splicing of introns to form EIciRNA or EcRNA; B intron-pairing-driven circularization: pre-mRNA contained abundant complementary sequence in introns flanking the exons can connect to form EIciRNA or EcRNA by base pairing; C RBPs driven circularization: intronic motifs flanking exons have RBPs binding sites which can interact with RBPs and induce circularization, in this process, EIciRNA or EcRNA can be produced; D intron cyclization: pre-mRNA conduct internal splicing to remove introns and generate mature mRNA. Some spliced introns can circularization to form ciRNA; E the formation of tricRNAs: induced by tRNA splicing endonuclease (TSEN) which can recognize bulge-helix-bulge (BHB) motif, pre-tRNA can undergo internal splicing to generate tricRNA and tRNA

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