Fig. 1

Schematic representation depicting the structure of YAP1 gene and protein. A YAP gene is located on 11q22.1. There are nine known isoforms of YAP, of which YAP1 isoform 1 (NM_001130145.3) is the most common transcript variant and contains 9 exons. B Schematic structure of human YAP1 proteins. TBD, TEAD-binding domain; WW, W-containing domain; CC, coiled-coil domain; TAD, transactivation domain