MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer

Hamidi, Amir Abbas; Taghehchian, Negin; Basirat, Zahra; Zangouei, Amir Sadra; Moghbeli, Meysam

doi:10.1186/s40364-022-00382-4

Biomarker Research

Table 2 All of the microRNAs associated with tumor cell migration and invasion in thyroid cancer

From: MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer

microRNA	Target	Results	Clinical Application	Samples	Country	Year	Study
PI3K/AKT Signaling
miR-497	AKT3	MiR-497 inhibited PTC cells migration and invasion through AKT3 suppression.	Diagnosis	43 patients 5 cell lines	China	2017	Zhuang [41]
miR-145	AKT3	MiR-145 targeted the AKT3, N-cadherin, and HIF1a during TC progression.	Diagnosis and prognosis (liquid biopsy)	3 cell lines	USA	2014	Boufraqech [42]
miR-217	AKT3	The miR-217 down regulation was also associated with clinical stage and lymphatic metastasis.	Diagnosis and prognosis	58 patients 4 cell lines	China	2017	Lin [43]
miR-203	AKT3	MiR-203 up regulation and AKT3 down regulation reduced tumor cell migration.	Diagnosis	105 patients 6 cell lines	China	2020	You [44]
miR-338-3p	AKT3	MiR-338-3p significantly suppressed the cell migration of TC cells by targeting AKT3.	Diagnosis and prognosis	48 patients 4 cell lines	China	2017	Sui [45]
miR-29a	AKT3	MiR-29a suppressed PTC cell migration and invasion by targeting AKT3.	Diagnosis and prognosis	30 patients 1 cell line	China	2016	Li [46]
Let-7a	AKT2	Let-7a significantly inhibited the PTC migration and invasion by targeting AKT2.	Diagnosis	47 patients 3 cell lines	China	2017	Zhou [47]
miR-718	PDPK1	MiR-718 suppressed PTC cell migration through PDPK1 targeting.	Diagnosis	15 patients 2 cell lines	China	2018	Wang [48]
miR-125b	PIK3CD	MiR-125b targets PIK3CD and inhibits the ATC cell migration.	Diagnosis	30 patients 3 cell lines	China	2017	Bu [49]
miR-363-3p	PIK3CA	MiR-363-3p repressed migratory and invasive behaviors of PTC cells via PIK3CA targeting.	Diagnosis and prognosis	30 patients 4 cell lines	China	2017	Liu [50]
miR-135a-5p	PPM1E	LINC01087 induced TC cell migration via miR-135a-5p/PPM1E axis.	Diagnosis	30 patients 2 cell lines	China	2022	Yin [51]
miR-646	HNRNPA1	CircTIAM1 induced PTC cell migration through the miR-646/HNRNPA1 axis	Diagnosis	60 patients 6 cell lines	China	2022	Zhang [52]
MiR-30b-5p	GALNT7	MiR-30b-5p inhibited PTC cell proliferation and migration by GALNT7 targeting	Diagnosis and prognosis	60 patients 3 cell lines	China	2021	Wang [53]
miR-141	IRS2	MiR-141 inhibited cell migration and invasive capability of thyroid tumor cells by IRS2 targeting.	Diagnosis and prognosis	30 patients 1 cell line	China	2016	Dong [54]
miR-766	IRS2	MiR-766 inhibited the malignant activity of PTC cells through IRS2 suppression.	Diagnosis and prognosis	47 patients 4 cell lines	China	2019	Zhao [55]
miR-215	ARFGEF1	MiR-215 suppressed PTC metastasis by regulating the AKT/GSK-3β/Snail cascade and ARFGEF1 targeting.	Diagnosis and prognosis	48 patients 4 cell lines	China	2019	Han [56]
miR-451a	MIF	MiR-451a down regulation in PTC samples was significantly correlated with the aggressive PTC and advanced TNM stage.	Diagnosis and prognosis	19 patients 5 cell lines	Italy	2016	Minna [57]
miR-146b	PTEN	MiR-146b is involved in regulation of PTEN/PI3K/AKT pathway during thyroid tumor aggressiveness.	Diagnosis	2 cell lines	Spain	2018	Ramírez-Moya [58]
MiR-671-5p	TRIM14	MiR-671-5p inhibited the PTC cell migration by TRIM14 targeting.	Diagnosis	2 cell lines	China	2021	Wang [59]
miR-215-5p	TRIM44	CircWDR27 increased PTC cell migration by regulation of the miR-215-5p/TRIM44 axis.	Diagnosis	42 patients 2 cell lines	China	2021	Wang [60]
miR-627	TRIM44	LINC00958 increased PTC cell migration by miR-627 sponging and TRIM44 up regulation.	Diagnosis	10 patients 3 cell lines	China	2022	Li [61]
WNT and Hippo Signaling
miR-3619-3p	b-catenin	MiR-3619-3p promoted the migratory and invasive capability of PTC cells through increased b-catenin mRNA stability.	Diagnosis and prognosis	36 patients 4 cell lines	China	2019	Yu [62]
miR-126	LRP6	MiR-126 up regulation suppressed PTC cells migration and in vivo tumor growth through LRP6 suppression.	Diagnosis and prognosis	30 patients 2 cell lines	China	2015	Wen [63]
miR-381-3p	LRP6	MiR-381-3p was associated with PTC metastasis through LRP6 down regulation.	Diagnosis and prognosis	8 patients 4 cell lines	China	2018	Kong [64]
miR-26a-5p	WNT5a	MiR-26a-5p inhibited the PTC cell growth, invasion, and metastasis via WNT5a suppression.	Diagnosis	58 patients 3 cell lines	China	2019	Shi [65]
miR-329	WNT1	MiR-329 inhibited the cell migration, invasion, and in vivo tumor growth via WNT1 suppression.	Diagnosis	20 patients 3 cell lines	China	2018	Wu [66]
miR-574-5p	FOXN3	MiR-574-5p mediated TC cell proliferation and migration through the Wnt/β-catenin pathway by targeting FOXN3.	Diagnosis	2 cell lines	China	2020	Zhang [67]
miR-1270	SCAI	MiR-1270 was involved in PTC progression through SCAI targeting.	Diagnosis	16 patients 5 cell lines	China	2019	Yi [68]
miR-625-3p	AEG1	MiR-625-3p enhanced TC cell migration and invasion by AEG-1 up regulation and triggering WNT pathway.	Diagnosis	20 patients 2 cell lines	China	2018	Fang [69]
miR-564	AEG1	Negative role of miR-564 on PTC migration and invasion via AEG1 inhibition.	Diagnosis and prognosis	47 patients 4 cell lines	China	2019	Song [70]
miR-205	YAP1	MiR-205 inhibited the Hippo signaling by targeting YAP1 and prevented TC cell migration and invasion.	Diagnosis	132 patients 4 cell lines	China	2018	Li [71]
miR34c5p	CRABP2	LINC01816 increased TC cell migration and EMT process via miR34c5p/CRABP2 axis.	Diagnosis	10 patients 5 cell lines	China	2021	Zhao [72]
TGFβ Signaling
miR-663	TGFβ	MiR-663 reduced PTC cell invasion, migration, and EMT via TGFβ inhibition.	Diagnosis and prognosis	91 patients 2 cell lines	China	2016	Wang [73]
miR-146b-5p	SMAD4	MiR-146b-5p was involved in PTC cell migration through SMAD4 targeting.	Diagnosis	2 cell lines	Brazil	2016	Lima [74]
miR-483	PARD3	MiR-483 up regulated the Tiam1-Rac1 signals through PARD3 down regulation.	Diagnosis	80 patients 4 cell lines	China	2019	Zhang [75]
Cytokines
miR-155	SOCS1	MiR-155 enhanced tumor progression by SOCS1 suppression.	Diagnosis and prognosis	31 patients 2 cell lines	China	2019	Zhang [76]
miR-25	SOCS4	MiR-25 enhanced the TC migration via targeting SOCS4.	Diagnosis	35 patients 2 cell lines	China	2015	Mei [77]
miR-126	CXCR4	MiR-126 reduced tumor cell migration and invasion via CXCR4 targeting.	Diagnosis	20 patients 2 cell lines	China	2016	Qian [78]
miR-223-3p	CXCR4	DUXAP8 induced PTC cell migration and proliferation through the regulation of miR-223-3p/CXCR4 axis.	Diagnosis	4 cell lines	China	2021	Liu [79]
miR-137	CXCL12	MiR-137 inhibited PTC cell proliferation, migration, and invasion by targeting CXCL12.	Diagnosis and prognosis	30 patients 1 cell line	China	2016	Dong [80]
MiR-455-5p	CXCL12	MiR-455-5p suppressed EMT and invasion in MTC cells by CXCL12 targeting.	Diagnosis and prognosis	28 patients 2 cell lines	China	2021	Zheng [81]
miR-1	CXCR4 and SDF-1	MiR-1 regulated the TC cell migration through CXCR4 and SDF-1 suppression.	Diagnosis	6 cell lines	Italy	2011	Leone [82]
miR-873-5p	CXCL16	MiR-873-5p inhibited PTC cells migration and invasion by targeting CXCL16.	Diagnosis	30 patients 6 cell lines	China	2020	Wang [83]
Kinases
miR-497	BDNF	MiR-497 suppressed cells migration through BDNF targeting.	Diagnosis and prognosis	48 patients 1 cell line	China	2017	Wang [84]
miR-26b-5p	MET	Circ-0079558 promoted the PTC cell proliferation and migration, while reduced apoptosis via miR-26b-5p/MET/AKT axis.	Diagnosis	30 patients 2 cell lines	China	2021	Zheng [85]
miR-375	ERBB2	MiR-375 reduced PTC cell migration and invasion through ERBB2 suppression.	Diagnosis	60 patients 3 cell lines	China	2016	Wang [86]
miR-195	VEGFA	CircPVT1 promoted the PTC cell migration by miR-195 sponging and subsequent VEGFA up regulation.	Diagnosis	50 patients 4 cell lines	China	2021	Zeng [87]
miR-520a-3p	JAK1	MiR-520a-3p inhibited the JAK-STAT signaling by JAK1 suppression which inhibited EMT and migration of PTC cells.	Diagnosis	137 patients 6 cell lines	China	2019	Bi [88]
miR-361-5p	ROCK1	MiR-361-5p inhibited PTC cells migration by ROCK1 targeting.	Diagnosis and prognosis	48 patients 4 cell lines	China	2018	Li [89]
miR-150-5p	ROCK1	MiR-150-5p inhibited PTC cell migration through ROCK1.	Diagnosis and prognosis	45 patients 5 cell lines	China	2017	Cheng [90]
miR-128	SPHK1	MiR-128 reduced TC cell migration and invasion via targeting SPHK1.	Diagnosis	30 patients 8 cell lines	China	2019	Cao [91]
miR-577	SPHK2	MiR-577 inhibited PTC cells migration and invasion through SPHK2 suppression.	Diagnosis	35 patients 4 cell lines	China	2017	Xue [92]
miR-613	SPHK2	MiR-613 inhibited the PTC cell migration, invasion, and in vivo growth by targeting SPHK2.	Diagnosis	20 patients 4 cell lines	China	2016	Qiu [93]
miR-539	CARMA1	MiR-539 is a modulator of TC cell migration and invasion by targeting CARMA1.	Diagnosis	31 patients 1 cell line	China	2015	Gu [94]
miR-675	MAPK1	MiR-675 inhibited PTC cell migration and in vivo growth through MAPK1 regulation.	Diagnosis and prognosis	57 patients 4 cell lines	China	2019	Wang [95]
miR-7	PAK1	MiR-7 inhibited TC cells migration and invasion through targeting PAK1.	Diagnosis and prognosis	32 patients 2 cell lines	China	2016	Yue [96]
miR-101	RAC1	MiR-101 repressed PTC cell invasion and migration through RAC1 targeting.	Diagnosis	16 patients 3 cell lines	China	2014	Wang [97]
Transcriptional Regulation And Transcription Factors
let-7b	HMGA2	Let-7b inhibited PTC cell migration and invasion through HMGA2 targeting.	Diagnosis	20 patients 5 cell lines	China	2017	Li [98]
let-7e	HMGB1	Let-7e suppressed PTC migration through HMGB1 targeting.	Diagnosis	2 cell lines	China	2019	Ding [99]
miR-212	SIRT1	MiR-212 inhibited cell proliferation, migration, and in vivo growth through SIRT1 targeting.	Diagnosis and prognosis	42 patients 4 cell lines	China	2018	Li [100]
miR-144	ZEB1 and ZEB2	MiR-144 suppressed migration of thyroid tumor cells through targeting ZEB1 and ZEB2.	Diagnosis	42 patients 2 cell lines	China	2015	Guan [101]
miR-429	ZEB1	MiR-429 suppressed TC cell migration through ZEB1 targeting.	Diagnosis	59 patients 3 cell lines	China	2019	Wu [102]
miR-335	ZEB2	MiR-335 suppressed TC cell migration through ZEB2 targeting.	Diagnosis	59 patients 5 cell lines	China	2017	Kan [103]
miR-194	ZEB1	CircVANGL1 promoted PTC cell migration and EMT process miR-194 sponging and ZEB1 up regulation.	Diagnosis and prognosis	77 patients 3 cell lines	China	2022	Xiang [104]
miR-30a	E2F7	MiR-30a inhibited the PTC cell migration by targeting E2F7.	Diagnosis	15 patients 2 cell lines	China	2019	Guo [105]
miR-544	YY1	MiR-544 suppressed tumor metastasis by targeting YY1.	Diagnosis	40 patients 4 cell lines	China	2019	Wang [106]
miR-211-5p	SOX11	MiR-211-5p suppressed TC cells migration and invasion by SOX11 targeting.	Diagnosis	40 patients 4 cell lines	China	2018	Wang [107]
miR-423-5p	SOX4	Circ_0039411 increased PTC cell migration through the regulation of miR-423-5p/SOX4 axis.	Diagnosis	51 patients 2 cell lines	China	2021	Wen [108]
miR-25 and miR-30d	EZH2	MiR-25 and miR-30d had a crucial role in ATC progression through EZH2 targeting.	Diagnosis	11 patients 3 cell lines	France	2012	Esposito [109]
miR-524-5p	FOXE1	MiR-524-5p modulated the PTC cell invasion, migration, and proliferation through FOXE1 suppression.	Diagnosis	57 patients 3 cell lines	China	2019	Liu [110]
miR-206	MRTFA	MiR-206 suppressed ATC cells migration through MRTFA targeting.	Diagnosis	19 patients 2 cell lines	China	2015	Zhang [111]
miR-637	LMO4	Knockdown of circLDLR reduced PTC cell migration, while promoted apoptosis by miR-637/LMO4 axis.	Diagnosis	45 patients 2 cell lines	China	2021	Jiang [112]
Membrane Associated And Extra Cellular Factors
miR-206	RAP1B	MiR-206 significantly decreased TPC-1 migration through RAP1B targeting.	Diagnosis	60 patients 5 cell lines	China	2019	Wang [113]
miR-126-3p	SLC7A5 and ADAM9	MiR-126-3p suppressed TC cell proliferation, migration, and distant metastasis through SLC7A5 and ADAM9 targeting.	Diagnosis and prognosis	496 patients 3 cell lines	USA	2015	Xiong [114]
miR-30a	LOX	MiR-30a inhibited ATC cell migration and invasion via LOX suppression.	Diagnosis and prognosis	14 patients 4 cell lines	USA	2015	Boufraqech [115]
MiR-613	TAGLN2	MiR-613 inhibited PTC cell invasion and EMT via TAGLN2 targeting.	Diagnosis and prognosis	107 patients 3 cell lines	China	2021	Huang [116]
miR-1231	GPX4	CircKIF4A promoted the PTC cell migration while inhibited ferroptosis by miR-1231 sponging and subsequent GPX4 up regulation.	Diagnosis	3 cell lines	China	2021	Chen [117]
Apoptosis And Protein Degradation
miR-618	XIAP	MiR-618 repressed ATC cell migration and invasion by targeting XIAP.	Diagnosis and prognosis	2 cell lines	China	2014	Cheng [118]
miR-15	BCL-2	MiR-15 inhibited MDA-T35 cells migration through BCL-2 suppression.	Diagnosis	4 cell lines	China	2019	Lu [119]
miR-34a-5p	TP73	CASC7 suppressed the PTC cell proliferation and migration by miR-34a-5p sponging and TP73 up regulation.	Diagnosis	30 patients 2 cell lines	China	2021	Sun [120]
miR-214	PSMD10	MiR-214 suppressed PTC cell migration and EMT via PSMD10 targeting.	Diagnosis and prognosis	30 patients 2 cell lines	China	2018	Liu [121]
miR-4319	SMURF1	MiR-4319 repressed the TC cell migration and EMT through SMURF1 targeting.	Diagnosis and prognosis	56 patients 5 cell lines	China	2020	Bian [122]
MiR-192-5p	SH3RF3	MiR-192-5p reduced PTC cell migration and EMT, while increased apoptosis by SH3RF3 targeting.	Diagnosis	20 patients 3 cell lines	China	2021	Fu [123]

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ISSN: 2050-7771

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