Fig. 3
From: The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies
The role of circ-IARS in tumor invasion and metastasis. Overexpression of circ-IARS can competitively adsorb miR-122 that alleviates its inhibition of RhoA activity, which increases F-actin expression and promotes cell contraction. Moreover, increasing RhoA activity reduced the expression of ZO-1, which disrupted the tight connection with endothelial cells, and eventually led to increased vascular endothelial permeability and promoted tumor metastasis