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Table 2 New studies in the field of IEXs therapeutic application

From: Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

Study name

source

year

ref

Anti-CTLA-4 antibody-functionalized dendritic cell-derived exosomes targeting tumor-draining lymph nodes for effective induction of antitumor T-cell responses

DC

2020

[119]

Exosome-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1

DC

2020

[120]

Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo

DC

2020

[121]

M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment

M1 macrophage

2020

[122]

M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation

M2 macrophage

2020

[123]

Neutrophil-derived exosome from systemic sclerosis inhibits the proliferation and migration of endothelial cells

Neutrophil

2020

[124]

miR103a-3p in exosomes derived from human mast cells (MCs) following aggregation of FcεRI enhances IL-5 production from IL-33-stimulated type2 innate lymphoid cells (ILC2) via silencing protein arginine methyltransferase (PRMT)

Mast cells

2020

[125]

Eosinophil-Derived Exosomes Contribute to Asthma Remodeling by Activating Structural Lung Cells

Eosinophil

2018

[126]

NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice

NK cell

2020

[127]

Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes

NK cell

2020

[128]

Role of Chronic Lymphocytic Leukemia (CLL)-Derived Exosomes in Tumor Progression and Survival

B cell

2020

[129]

Exosomes derived from regulatory T cells ameliorate acute myocardial infarction by promoting macrophage M2 polarization

Treg

2020

[130]

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

CAR-T

2019

[131]

  1. DC Dendritic cell, CAR-T cell Chimeric antigen receptor expressing T cell, Treg Regulatory T cell