Fig. 4
From: Targeting CD47/SIRPα as a therapeutic strategy, where we are and where we are headed
Types of bis-specific molecules targeted CD47 and other molecules. Bispecific Ab-type 1: KIH format, targeted to CD47 (yellow) and other tumor associated antigens (CD19, CD20, and MSLN, blue); Bi-specific Ab-type 2: KIH format, targeted to CD47 (yellow) and immune checkpoint molecules (PD-1, CD40, and 41BB, green); Bi-specific Ab-type 3: SIRPα (cyan) fusion to N-terminus of H-chain of IgG (targeting tumor associated antigen, blue); Bi-specific Ab-type 4: ligand/receptor to modulate TME (GM-CSF, and VEGFR2, pink) fusion to the C-terminus of the H-chain of IgG (yellow); Bi-specific Ab-type 4: SIRPα fusion to the N-terminus of IgG-Fc and ligand/receptor to modulate TME (GM-CSF, VEGFR2, pink) fusion to the C-terminus