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Fig. 3 | Biomarker Research

Fig. 3

From: Targeting CD47/SIRPα as a therapeutic strategy, where we are and where we are headed

Fig. 3

Mechanism of action of interruption of the CD47/SIRPα axis. Three mechanisms can be used to inhibit the CD47/SIRPα interaction. Phagocytosis (the most important mechanism of action): blocks the CD47/SIRPα interaction to remove inhibitory signals and promote phagocytosis of tumor cells; Antigen presentation: antiCD47 antibody connects tumor cells and SIRPα+ DCs to promote antigen presentation; Apoptosis: some antiCD47 antibodies could induce tumor cell poptosis

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