Fig. 2From: Targeting CD47/SIRPα as a therapeutic strategy, where we are and where we are headedBiology of CD47/SIRPα interaction. CD47 binds to SIRPα to transmit inhibitory signals to macrophages and to inhibit or lessen phagocytic activity through uncoupling of receptor binding and signal transduction. Therapeutic agents block the interaction between CD47 and SIRPα to remove the inhibitory signal and restore the phagocytic activityBack to article page