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Fig. 1 | Biomarker Research

Fig. 1

From: Targeting CD47/SIRPα as a therapeutic strategy, where we are and where we are headed

Fig. 1

Diagram of composition of CD47 and SIRPα protein. The upper panel is the SIRPα protein with signal region (1–30), Ig-like V-type (32–137), Ig-like C1-type1 (148–247), C1-type2 (254–348), transmembrane (helical, 374–394), and cytoplasmic region (365–504) with four short spacers for SH2-binding. The lower is the CD47 protein with signal region (1–18), extracellular domain (19–141), five transmembrane region (142–289, Helical 1 to Helical 5), and cytoplasmic region (290–323)

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