Fig. 4

Various types of VHH-based CAR-Ts. Bispecific VHH-based CAR-Ts have a targeting domain made by fusing two VHHs using a linker. Moreover, fourth-generation VHH-based CAR-Ts are CAR-Ts genetically manipulated to secrete a cytokine of interest or a particular type of targeting moiety (such as VHHs). nanoCAR-T, VHH-based CAR-T; VHH, single variable domain on a heavy chain