Fig. 3
scFv aggregation on the surface of CAR-Ts. There are two action mechanisms following which scFv aggregation occurs on the surface of CAR-Ts. The first mechanism (left panel) is called VH-VL mispairing and involves the paring between the VL domain from one CAR with the VH domain of another CAR. The second mechanism (right panel) is termed VH-VH pairing and happens when the VH domain of a CAR pairs with a VH domain from another CAR. VH, heavy chain variable domain; VL, light chain variable domain