From: The role of ncRNAs in neuroblastoma: mechanisms, biomarkers and therapeutic targets
Biomarker | Alter-ation | Study sample | Mechanism | Risk-classification | Ref |
---|---|---|---|---|---|
miR-29a + miR-30c + miR-95 + miR-128a + miR-128b + miR-137 + miR-138 + miR-148a + miR-195 + age + Dicer+Drosha | – | 66 primary NB specimens | – | Separate patients into four distinct patterns | [69] |
miR-487b + miR-410 | Down | 227 patients staged from INSS | – | High risk | [70] |
hsa-miR199a-3p | Up | 17 NB specimens | decreasing NEDD4 expression | poor prognosis | [67] |
CAI2 | Up | 62 primary NB specimens | Regulating P16 expression | High risk | [71] |
FOXD3-AS1 | – | Dataset of 88 NB cases and 64 neuroblastic tumours with GEO accession | Repressing activation of CTCF | favourable outcome | [30] |
NBAT-1 | Down | three low-risk and 12 high-risk tumours | Activation of NRSF/REST | adverse outcome | [19] |
SNHG7 | Up | 92 pairs of NB specimens and adjacent non-tumour specimens | interact with miR-653-5p | poor prognosis | [41] |
DLX6-AS1 | Up | 36 NB specimens | interact with miR-107 | advanced TNM stage | [72] |
lncRNA-uc003opf.1 | – | 275 patients and 531 controls | decreasing LRFN2 expression | decreased NB risk | [73] |