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Table 1 NcRNAs as risk-classification biomarkers in NB

From: The role of ncRNAs in neuroblastoma: mechanisms, biomarkers and therapeutic targets

Biomarker

Alter-ation

Study sample

Mechanism

Risk-classification

Ref

miR-29a + miR-30c + miR-95 + miR-128a + miR-128b + miR-137 + miR-138 + miR-148a + miR-195 + age + Dicer+Drosha

–

66 primary NB specimens

–

Separate patients into four distinct patterns

[69]

miR-487b + miR-410

Down

227 patients staged from INSS

–

High risk

[70]

hsa-miR199a-3p

Up

17 NB specimens

decreasing NEDD4 expression

poor prognosis

[67]

CAI2

Up

62 primary NB specimens

Regulating P16 expression

High risk

[71]

FOXD3-AS1

–

Dataset of 88 NB cases and 64 neuroblastic tumours with GEO accession

Repressing activation of CTCF

favourable outcome

[30]

NBAT-1

Down

three low-risk and 12 high-risk tumours

Activation of NRSF/REST

adverse outcome

[19]

SNHG7

Up

92 pairs of NB specimens and adjacent non-tumour specimens

interact with miR-653-5p

poor prognosis

[41]

DLX6-AS1

Up

36 NB specimens

interact with miR-107

advanced TNM stage

[72]

lncRNA-uc003opf.1

–

275 patients and 531 controls

decreasing LRFN2 expression

decreased NB risk

[73]