Fig. 4
From: The role of ncRNAs in neuroblastoma: mechanisms, biomarkers and therapeutic targets
Principle of single-stranded oligonucleotides targeting miRNAs and lncRNAs. Single-stranded antisense oligonucleotides can induce miRNA degradation through the recognition and processing of the RNA-induced silencing complex (RISC). RNaseH and RISC can recognize and induce the degradation of lncRNAs. Several types of vectors allow oligonucleotides to penetrate into the cytoplasm; thus, a variety of drug delivery strategies, including lipoplexes, polymeric nanoparticles, exosomes, and expression vectors, can be used