Table 1 Role of hnRNP C regulation and dysregulation in cancers
From: An analysis of the role of HnRNP C dysregulation in cancers
Cancer | hnRNP C Imbalance type | Interacting molecule | Consequence |
|---|---|---|---|
Nonsmall Cell Lung Cancer (NSCLC) | Up regulated | KHSRP protein | IFN-α-JAK-STAT1 axis activated, promoting invision and metastasis [38]. |
Glioblastoma multiform (GBM) | Up regulated | MiR-21 | PDCD4 decreased. Promoting Migration and invision [42]. |
Ovarian serous cystadeno carcinoma | Up regulated | MiR-774-5p | Bcl2 levels downregulated. Promoting apoptotic [43]. |
Brain-trophic metastatic MDA-MB-435-LvBr2 (LvBr2) cells | UP regulated | MiR-146a | Promoting Migration and invision of LvBr2 cells [44]. |
Esophageal squamous cell carcinoma (ESCC) | Up regulated | LBX2-AS1 (lncRNA) | enhance the stability of ZEB1 and ZEB2 mRNAs. promoting cell EMT and migration in ESCC [45]. |
Oral squamous cell carcinoma (OSCC) | Up regulated | LINC00662 | regulate AK4 mRNA stability. reduced the radiosensitivity of OSCC cells [46]. |
Breast cancer | Down regulated | dsRNA | trigger IFN response inhibit proliferation and tumor growth [35]. |
Colon cancer | Up regulated | URT of gene | drive CR- and UTR-APA in MTHFD1L [40]. |
Most of cancers | Up regulated. | As a reader Of m6A | has a potential as a biomaker. |