Skip to main content

Table 1 Role of hnRNP C regulation and dysregulation in cancers

From: An analysis of the role of HnRNP C dysregulation in cancers

Cancer hnRNP C
Imbalance type
Interacting molecule Consequence
Nonsmall Cell Lung Cancer (NSCLC) Up regulated KHSRP protein IFN-α-JAK-STAT1 axis activated, promoting invision and metastasis [38].
Glioblastoma multiform (GBM) Up regulated MiR-21 PDCD4 decreased.
Promoting Migration and invision [42].
Ovarian serous cystadeno carcinoma Up regulated MiR-774-5p Bcl2 levels downregulated.
Promoting apoptotic [43].
Brain-trophic metastatic MDA-MB-435-LvBr2 (LvBr2) cells UP regulated MiR-146a Promoting Migration and invision of LvBr2 cells [44].
Esophageal squamous cell carcinoma (ESCC) Up regulated LBX2-AS1 (lncRNA) enhance the stability of ZEB1 and ZEB2 mRNAs.
promoting cell EMT and migration in ESCC [45].
Oral squamous cell carcinoma (OSCC) Up regulated LINC00662 regulate AK4 mRNA stability.
reduced the radiosensitivity of OSCC cells [46].
Breast cancer Down regulated dsRNA trigger IFN response
inhibit proliferation and tumor growth [35].
Colon cancer Up regulated URT of gene drive CR- and UTR-APA in MTHFD1L [40].
Most of cancers Up regulated. As a reader
Of m6A
has a potential as a biomaker.