Table 1 The relationship between the changes of YAP and various types of PCD in different cells
Cell types | Upstream | YAP | Downstream | Pathway | Non-genetic contexts | PCD | Citation |
|---|---|---|---|---|---|---|---|
Hepatocellular cancer |  | YAP-TEAD | Jag-1↑ | Notch signaling |  | Anti-Apoptosis | [62] |
Breast cancer |  | YAP-TEAD | BCAR4↑ | Hedgehog signaling |  | Anti-Apoptosis | [63] |
Hepatocellular cancer | Fbxw7 | YAP-TEAD↓ |  | Proteasomal degradation |  | Apoptosis | [64] |
Urothelial cell cancer |  | YAP-TEAD↓ |  |  | DNA-damage | Apoptosis | [65] |
Breast cancer | Akt | YAP-p73↓ |  | Pro-apoptosis genes↓ |  | Anti-Apoptosis | [57] |
Colon cancer Breast cancer | c-Abl | YAP-p73↑ |  | Pro-apoptosis genes↑ | DNA-damage | Apoptosis | [58] |
Cholangiocarcinoma |  | YAP-TEAD | MFAP5↑ | Promotes angiogenesis |  | Anti-Apoptosis | [66] |
Colorectal cancer | GPRC5A | YAP↑ |  | Anti-apoptotic genes↑ | Hypoxia | Anti-Apoptosis | [67] |
Breast cancer |  | YAP-TEAD↑ |  | Autolysosome degradation | Nutrient deprivation | Autophagy | [68] |
Hepatocellular cancer |  | YAP↑ |  | RAC1-ROS-mTOR pathway | Multi-drug resistance | Anti-Autophagy | [69] |
Colorectal cancer |  | YAP-TEAD | Bcl-2↑ |  |  | Anti-Autophagy | [70] |
Glioblastoma |  | YAP | HMGB1↑ |  |  | Autophagy | [71] |
Epithelial cell | NF2 | YAP-TEAD↓ |  | Hippo pathway | High cell density | Sensitivity of Ferroptosis↓ | [72] |