Table 1 Targets for CAR-NK cell generation
From: CAR-NK cells for cancer immunotherapy: from bench to bedside
Target | Tumor | References |
|---|---|---|
CD19 | Acute lymphocytic leukemia (ALL) | Romanski, et al [67] |
CD7 | Acute lymphocytic leukemia (ALL) | You, et al [68] |
CD5 | Acute lymphocytic leukemia (ALL) | Xu, et al [69] |
FLT3 | Acute lymphocytic leukemia (ALL) | Oelsner, et al [70] |
CD33 | Acute myelocytic leukemia (AML) | Tang, et al [71] |
CD123 | Acute myelocytic leukemia (AML) | Klöß, et al [72] |
CD4 | Acute myelocytic leukemia (AML) | Pinz, et al [73] |
HER2 | Breast cancer | Schönfeld, et al [74] |
EpCAM | Breast cancer | Sahm, et al [75] |
TF | Breast cancer | Hu, et al [76] |
EGFR | Breast cancer | Chen, et al [77] |
NKG2D | Breast cancer | Chang, et al [78] |
CD19 | Chronic lymphocytic leukemia (CLL) | Boissel, et al [79] |
EpCAM | Colorectal cancer | Zhang, et al [80] |
CEA | Colorectal cancer | Shiozawa, et al [81] |
NKG2D | Colorectal cancer | Xiao, et al [82] |
GD2 | Ewing sarcoma | Kailayangiri, et al [83] |
HER2 | Gastric cancer | Wu, et al [84] |
EGFRvIII | Glioblastoma | Han, et al [85] |
EGFR | Glioblastoma | Han, et al [85] |
CD73 | Glioblastoma | Wang, et al [86] |
HER2 | Glioblastoma | Zhang, et al [87] |
ROBO1 | Glioma and Neuroblastoma | Qu, et al [88] |
GPC3 | Hepatocellular cancer (HCC) | Huang, et al [89] |
NKG2D | Hepatocellular cancer (HCC) | Chang, et al [78] |
c-MET | liver cancer | Liu, et al [90] |
NKG2D | Lung cancer | Lu, et al [91] |
Target | Tumor | References |
B7-H3 | Lung cancer | Yang, et al [92] |
CD19 | Lymphoma | Gang, et al [63] |
CD4 | Lymphoma | Pinz, et al [73] |
GPA7 | Melanoma | Zhang, et al [93] |
CD138 | Multiple Myeloma | Jiang, et al [94] |
CS1 | Multiple Myeloma | Chu, et al [95] |
BCMA | Multiple Myeloma | Ng, et al [96] |
GD2 | Neuroblastoma | Esser, et al [97] |
CD276 | Neuroblastoma | Elahi, et al [98] |
aFR | Ovarian cancer | Ao, et al [99] |
HER2 | Ovarian cancer | Kruschinski, et al [100] |
Mesothelin | Ovarian cancer | Cao, et al [101] |
GPC3 | Ovarian cancer | Ueda, et al [102] |
NKG2D | Ovarian cancer | Ng, et al [103] |
Mesothelin | Pancreatic cancer | Batchu, et al [104] |
ROBO1 | Pancreatic cancer | Li, et al [105] |
PSMA | Prostate | Montagner, et al [106] |
HER2 | Renal cell carcinoma (RCC) | Schonfeld, et al [74] |
EGFR | Renal cell carcinoma (RCC) | Zhang, et al [107] |
PSCA | Ladder carcinoma | Topfer, et al [108] |
HLA-G | Kidney renal clear cell carcinoma, Kidney renal papillary cell carcinoma, Pancreatic ductal adenocarcinoma, Thyroid cancer | Jian, et al [109] |
Mesothelin | Ovarian cancer | Li, et al [59] |
CD20 | Lymphoma, Leukemia cells | Muller, et al [110] |
NKG2D | Osteosarcoma | Chang, et al [78] |