Fig. 4

KSR2 promotes HCC growth in vivo. A, B KSR2 knockdown affects the ability of PLC/PRF/5 cells to form tumors in nude mice. C, D Overexpression of KSR2 affects the size of tumors derived from PLC/PRF/5 cells in nude mice. E, F Change in volume over time of subcutaneous tumors formed by cells with KRS2 overexpression and knockdown, relative to the control group. G, H Differences between the weight of the subcutaneous tumors formed after manipulating KSR2 levels and the weight of control tumors. I Immunohistochemical staining of subcutaneous tumor sections g KSR2 overexpression group, knockdown group, and control group. J The ratio of KI67 positive cells in the KSR2 overexpression group, knockdown group, and control group. *p < 0.05; **p < 0.01; ***p < 0.001