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Table 3 Comparative studies involving chemoimmunotherapy and combinations of novel agents

From: Combining BTK inhibitors with BCL2 inhibitors for treating chronic lymphocytic leukemia and mantle cell lymphoma

Comparisons

Trial

Phase

Patients

FCR vs I + V

NCT04010968

2

TN CLL(fit)

FCR/BR vs V + R vs V + O vs I + V + O

NCT02950051

3

TN CLL(fit)

FCR/BR vs A + V ± O

NCT03836261

3

TN CLL

I + V vs Chl + O

NCT03462719

3

TN CLL/SLL

I + O vs I + O + V

NCT03737981

3

TN CLL/SLL(older)

NCT03701282

3

TN CLL/SLL(younger)

I vs I + V vs V + O

NCT04608318

3

TN CLL

A + V vs V + O

NCT05057494

3

TN CLL/SLL

  1. A acalabrutinib, BR bendamustine and rituximab, Chl chlorambucil, CLL/SLL chronic lymphocytic leukemia/small lymphocytic lymphoma, FCR fludarabine, cyclophosphamide and rituximab, I ibrutinib, O obinutuzumab, R rituximab, V venetoclax, TN treatment-naïve