Table 5 Ongoing studies investigating CAR-T for HCC
From: Recent advances in systemic therapy for hepatocellular carcinoma
Study Title | Registration ID | Phase | Status | Results/Notes |
|---|---|---|---|---|
GPC3-targeted CAR-T Cell for Treating GPC3 Positive Advanced HCC | NCT04121273 | 1 | Recruiting | / |
Anti-GPC3 CAR T for Treating Patients with Advanced HCC | NCT02395250 | 1 | Completed | 6-month OS:50.3%; 1-year OS: 42.0%; 3-year OS: 10.5%, mOS: 278days (95% CI,48-615 days); 2 PRs, 1 SD |
CAR-GPC3 T Cells in Patients with Refractory Hepatocellular Carcinoma | NCT03146234 | / | Completed | |
Glypican 3-specific Chimeric Antigen Receptor Expressing T Cells for Hepatocellular Carcinoma (GLYCAR) | NCT02905188 | 1 | Recruiting | / |
GPC3-CAR-T Cells for the Hepatocellular Carcinoma | NCT04506983 | 1 | Not yet recruiting | / |
Anti-GPC3 CAR-T for Treating GPC3-positive Advanced Hepatocellular Carcinoma (HCC) | NCT03084380 | 1/2 | Unknown | / |
A Study of GPC3 Redirected Autologous T Cells for Advanced HCC | NCT02715362 | 1/2 | Unknown | / |
A Study of GPC3-targeted T Cells by Intratumor Injection for Advanced HCC (GPC3-CART) | NCT03130712 | 1/2 | Unknown | / |
GPC3-CAR-T Cells for Immunotherapy of Cancer with GPC3 Expression | NCT03198546 | 1 | Recruiting | / |
4th Generation Chimeric Antigen Receptor T Cells Targeting Glypican-3 | NCT03980288 | 1 | Recruiting | / |
Chimeric Antigen Receptor T Cells Targeting Glypican-3 | NCT03884751 | 1 | Recruiting | / |
Clinical Study of Redirected Autologous T Cells with a Chimeric Antigen Receptor in Patients with Malignant Tumors | NCT03302403 | / | Not recruiting | / |
Clinical Study on the Efficacy and Safety of c-Met/PD-L1 CAR-T Cell Injection in the Treatment of HCC | NCT03672305 | 1 | Unknown | / |
A Study of CD147-targeted CAR-T by Hepatic Artery Infusions for Very Advanced Hepatocellular Carcinoma | NCT03993743 | 1 | Recruiting | / |
Clinical Study of ET1402L1-CAR T Cells in AFP Expressing Hepatocellular Carcinoma | NCT03349255 | 1 | Terminated | Will study new T-cell construct for the same indication |
Autologous CAR-T/TCR-T Cell Immunotherapy for Solid Malignancies | NCT03941626 | 1/2 | Recruiting | / |
NKG2D CAR-T (KD-025) in the Treatment of Relapsed or Refractory NKG2DL+ Tumors | NCT04550663 | 1 | Not yet recruiting | / |
Phase I/II Study of Anti-Mucin1 (MUC1) CAR T Cells for Patients with MUC1+ Advanced Refractory Solid Tumor | NCT02587689 | 1/2 | Unknown | / |
A Clinical Research of CAR T Cells Targeting EpCAM Positive Cancer | NCT03013712 | 1/2 | Unknown | / |
Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies | NCT03638206 | 1/2 | Recruiting | / |