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Table 4 Antibody-drug conjugates and bispecific T cell engagers for HCC treatment

From: Recent advances in systemic therapy for hepatocellular carcinoma

Antibody-drug conjugates

ADCs

Payload

Target

Stage

Reference

Anti-CD147 ILs-DOX

doxorubicin

CD147

preclinical

[139]

G7mAb-DOX

doxorubicin

CD24

preclinical

[140]

MetFab-DOX

doxorubicin

c-MET

preclinical

[141]

IMMU-132

SN-38

Trop-2

phase I/II

[142]

hYP7-DC

duocarmycin SA

GPC3

preclinical

[143]

hYP7-PC

pyrrolobenzodiazepine

CLDN6-DM1

mertansine

CLDN6

preclinical

[144]

Bispecific T cell engagers

BiTEs

TAA

T cell receptor

Stage

Reference

1H8/CD3

EpCAM

CD3

preclinical

[145]

solitomab

EpCAM

CD3

phase I

[146]

ERY974

GPC3

CD3

phase I

[147]

  1. Abbreviations: CLDN6, Claudin6; EpCAM, epithelial cell adhesion molecule; GPC3, glypican-3; TAA, tumor associated antigen; Trop-2, trophoblast cell surface antigen-2