From: The role of phosphatidylserine on the membrane in immunity and blood coagulation
PtdSer binding recognition site | Immune receptor or coagulation factor | Ca2+ dependence | Function after binding to PtdSer | References |
---|---|---|---|---|
GLA domain | GAS6/PROS1 ligand of immune receptor TAM | Yes | Identify apoptotic cells (GAS6/PROS1), stable thrombosis and maintain platelet stability (GAS6) | |
Coagulation factor vitamin K-dependent proteins (Factor VIIa, IXa, Xa, prothrombin and activated protein C) | Yes | Coagulation and anticoagulation | ||
Discoidin-like C2 domain | MFG-E8 ligand of immune receptor αvβ3 or αvβ5 integrins | No | Identify apoptotic cells | |
Coagulation factor Factor Va and Factor VIIIa | No | Maintain protein stability | [191] | |
IgV-like domain | Immune receptor TIM family (TIM-1, TIM-3, TIM-4) | Yes | Identify apoptotic cells and promote endocytosis. | [35] |
Immune receptor CD300a | Yes | Identify apoptotic cells | [35] | |
Immune receptor RAGE | Not sure yet | Identify apoptotic cells | ||
TSP-1 | Immune receptor BAI1 | Not sure yet | Promote maximum phagocytosis of apoptotic cells | [66] |
EGF-like domain | Immune receptor stabilin-1 and stabilin-2 | Yes | Endocytosis and cell fusion |