Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

Biomarker Research

Table 2 Tumor-suppressive roles of ZFPs in HCC

ZFPs	Aliases	Role	Target genes	Mechanism in HCC	Ref
A20	TNFA1P2	TSG	Twist1	Inhibits proliferation and migration	[98]
			FAK、RAC1	Inhibits the motility and metastasis	[11]
			PFKL	Inhibits proliferation, migration and glycolysis	[108]
GATA4	TOF、ASD2	TSG	NF-κB1, NF-κB2, RELA	Induces the MET transition	[109]
ZNF307	ZKSCAN4	TSG	Caspase-3、BAX、BCL-2	Inhibits proliferation	[110]
ZNF191	ZNF24、ZSCAN3	TSG	DLG1	Inhibits metastasis of HCC	[111]
ZFP91	PZF、ZNF757	TSG	HNRNPA1	Inhibits glucose metabolic reprogramming, proliferation and metastasis	[112]
ZNF382	KS1	TSG	Fos、Jun、DVL2、FZD1	Activates the p53 signaling pathway	[12]
ZNF774		TSG	NOTCH2	Inhibits growth and metastasis of HCC	[13]
Miz1	ZBTB17、ZNF60	TSG	MTDH	Inhibits inflammation	[113]
ZNF521	EHZF、Evi3	TSG	Runx2	Inhibits growth	[14]

ISSN: 2050-7771