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Fig. 3 | Biomarker Research

Fig. 3

From: Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

Fig. 3

ZNF191 plays an opposite role in different stages of hepatocellular carcinoma. At early stage, ZNF191 activated the expression of CTNNB1 and its downstream gene Cyclin D1 by binding to the promoter region of CTNNB1, ultimately promoted the proliferation of HCC. At late stage, ZNF191 activated its expression by binding to the promoter of DLG1, thereby inhibited the activation of YAP and the migration of HCC cells, eventually inhibited the metastasis of HCC

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Biomarker Research

ISSN: 2050-7771

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