Study | Phase | Refractoriness | N | ORR (%) | ≥VGPR/CRR/MRD (%) | Median PFS (months) | Median OS (months) | Median DoR (months) |
---|---|---|---|---|---|---|---|---|
3 | V + R | 225 | 28 | 6/-/- | 3.7 | 11.1 | 7.0 | |
Pd - MM-010 [13] | 3 | V + R | 547 | 32.4 | 7.8/0.5/- | 4.2 | 11.9 | - |
D - SIRIUS [14] | 2 | PI + IMiD | 30 | 29.7 | - | - | - | - |
D - GEN501 + SIRIUS [169] | 2 | PI + IMiD | 148* | 30.4 | 14/5/- | 4.0 | 20.5 | 8.0 |
IPd – ICARIA-MM [170] | 3 | PI + R | 111 | 59 | 29.7/-/- | 11.2 | - | - |
DPd – APOLLO [53] | 3 | PI + IMiD | 64 | - | - | 7.7 | - | - |
DPd – MMY-1001 [68] | 1 | PI + IMiD | 73 | 57.5 | - | - | - | - |
3 | - | RR: 99 VR: 100 | RR: 79.8 VR: 79.0 | RR: -/-/13.1 VR: -/-/7.0 | RR: NA VR: 14.2 | - | - | |
DKd – MMY-1001 [171] | 1 | PI + IMiD | 25 | 83 | -/-/6.9 | 25.7 | NA 1y-OS 75% | - |
IKd – IKEMA [50] | 3 | - | RR: 57 VR: 52 | - | RR: 66.7/38.6/24.6 VR: 55.8/28.8/17.3 | RR: NA VR: NA | - | - |
EloPd – ELOQUENT-3 [78] | 2 | PI + R | 41 | - | - | 10.2 | - | - |
KPd – EMN07 [172] | 1/2 | V + R | 21 | 71 | 24/5/- | 10.3 | - | - |
Sd – STORM [65] | 2b | PI + IMiD + D | 122 | 26 | 6.56/1.64/- | 3.7 | 8.6 | 4.4 |
Belamaf – DREAMM-2 [94] | 2 | PI + IMiD + D | 97 | 32 | 18/7/- | 2.8 | 13.7 | 11 |