Agent | Target | Model | Mechanism | Refs |
---|---|---|---|---|
Adagrasib | KRAS | KRASG12C-positive patients | Inhibition of KRASG12C | 9 |
Ammonium ferric citrate | GPX4 | A549, HCC827, H1299, and NCI-H661 cells | Inhibition of GPX4-GSS/GSR-GGT axis | [125] |
BSO | GSH | Neuroendocrine SCLC cells | Inhibition of the GCLC | 129,130 |
Celastrol | ROS | HCC827, A540, and H1299 cells | Accumulation of damaged mitochondria and induction of PINK1/Parkin-dependent mitosis | [126] |
Cisplatin | GSH | A549 cells | Depletion of GSH | 125 |
Cryptotanshinone | ROS | A549 and NCI-H520 cells | Generation of the ROS and induction of lipid peroxidation | [127] |
Curcumin | GSH | A549 and H1299 cells | Activation of autophagy | [128] |
Dihydroartemisinin | ROS | NCI-H23 and XWLC-05 cells | Inhibition of the PRIM2-SLC7A11 axis | 113 |
Dihydroisotanshinone I | GPX4 | A549 and H460 cells | Downregulation of GPX4 expression | [129] |
Erastin | SLC7A11 | N5CP and A549 cells | Inhibition of NFE2L2-SLC7A11 pathway; upregulation and activation of TP53 | 77,86, [130] |
Erianin | CaM | H460 and H1299 cells | Induction of Ca2+/CaM signaling | 133 |
Ginkgetin | GSH | A549, NCIH460, and SPC-A-1 cells | Inhibition of SLC7A11 and GPX4; downregulation of GSH/GSSG ratio; disruption of the NFE2L2-HMOX1 axis | 85 |
6-Gingerol | USP14 | A549 cells | Inhibition of USP14 activity; upregulation of BECN1 and LC3-II/LC3-I | 131 |
Levobupivacaine | ROS | A549 and A427 cells | Up-regulation of TP53 | [131] |
Orlistat | Lipid peroxidation | A549 and H1299 cells | Inhibition of the expression of FAF2 | 137 |
Paracetamol | ROS | A549 and H1299 cells | Inhibition of NFE2L2-HMOX1 | 84 |
PdPT | GPX4 | A549 and H1299 cells | Induction of GPX4 degradation | 31 |
RSL3 | GPX4 | H1650, HCC827, and PC9 cells | Inhibition of GPX4 activity | [132] |
Siramesine and Lapatinib | ROS | A549 cells | Iron release from lysosomes and HMOX1 degradation by the proteasome system | [133] |
Sorafenib | SLC7A11 | N5CP and A549 sells | Inhibition of NFE2L2-HMOX1 pathway | 86, [130] |
Sulforaphane | GSH | NCI-H69, NCI-H82, and NCI-H69AR cells | Inhibition of SLC7A11 | [134] |
Zinc | ROS | A549 cells | Induction of lipid peroxidation | [135] |