Table 1 Clinicopathological parameters according to mesothelin and CA125 expression levels
Parameter | Total N=478 (%) | Number of cases (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
MSLN | CA125 | MSLN and CA125 co-expression | ||||||||
Positive N=75 (%) | Negative N=403 (%) | P-value | Positive N=217 (%) | Negative N=261 (%) | P-value | PositiveN=48 (%) | Negative N=430 (%) | P-value | ||
Age, years (mean±SD) | 60.3 (±11.6) | 58.9 (±11.3) | 0.33 | 57.7(±11.2) | 60.2 (±11.4) | 0.012 | 59.6(±11.6) | 60.3 (±11.3) | 0.90 | |
Pathological T factor | ||||||||||
T1 (<2 cm) | 264 | 31 (11.8) | 233 (88.2) | 0.030 | 125 (47.3) | 139 (52.7) | 0.054 | 19 (7.2) | 245 (92.8) | 0.049 |
T2 (2-5 cm) | 194 | 37 (19.1) | 157 (80.9) | 87 (44.8) | 107 (55.2) | 24 (12.4) | 170 (87.6) | |||
T3 (>5 cm) | 20 | 7 (35.0) | 13 (65.0) | 5 (25.0) | 15 (75.0) | 5 (25.0) | 15 (75.0) | |||
Pathological N factor | ||||||||||
pN1, pN2, pN3 | 178 | 29 (16.3) | 149 (83.7) | 0.78 | 79 (44.3) | 99 (55.6) | 0.73 | 23 (12.9) | 155 (87.1) | 0.11 |
pN0 | 300 | 46 (15.3) | 254 (84.6) | 138 (46.0) | 162 (54.0) | 25 (8.3) | 275 (91.7) | |||
Pathological Stage | ||||||||||
0-I | 201 | 27 (13.4) | 174 (86.6) | 0.13 | 100 (49.8) | 101 (50.2) | 0.26 | 16 (8.0) | 185 (92.0) | 0.12 |
II | 221 | 34 (15.4) | 187 (84.6) | 94 (42.5) | 127 (57.5) | 22 (10.0) | 199 (90.0) | |||
III | 56 | 14 (25.0) | 42 (75.0) | 23 (41.1) | 33 (58.9) | 10 (17.9) | 46 (82.1) | |||
Subtype | ||||||||||
ER/PgR+ and HER2- | 333 | 31 (9.3) | 302 (90.7) | <0.0001 | 137 (41.1) | 196 (58.9) | 0.0028 | 17 (5.1) | 316 (94.9) | < 0.0001 |
ER/PgR+ and HER2+ | 30 | 1 (3.3) | 29 (96.7) | 15 (50.0) | 15 (50.0) | 0 (0.0) | 30 (100.0) | |||
HER2+ | 34 | 7 (20.6) | 27 (79.4) | 16 (47.0) | 18 (53.0) | 4 (11.8) | 30 (88.2) | |||
TNBC | 81 | 36 (44.4) | 45 (55.6) | 49 (60.5) | 32 (39.5) | 27 (33.3) | 54 (66.7) | |||
Lymphatic permeation | ||||||||||
Positive | 284 | 46 (16.2) | 238 (83.8) | 0.71 | 123 (43.3) | 161 (56.6) | 0.27 | 24 (8.5) | 260 (91.5) | 0.16 |
Negative | 194 | 29 (14.9) | 165 (85.1) | 94 (48.5) | 100 (51.5) | 24 (12.4) | 170 (87.6) | |||
Nuclear grade | ||||||||||
1 | 117 | 12 (10.3) | 105 (89.7) | < 0.0001 | 55 (47.0) | 62 (53.0) | 0.22 | 7 (6.0) | 110 (94.0) | < 0.0001 |
2 | 140 | 4 (2.9) | 136 (97.1) | 55 (39.3) | 85 (60.7) | 3 (2.1) | 137 (97.9) | |||
3 | 221 | 59 (42.1) | 162 (57.9) | 107 (48.4) | 114 (51.6) | 38 (17.2) | 183 (82.8) | |||
Ki-67 labeling index (%) | ||||||||||
≥14 | 298 | 33 (11.1) | 265 (88.9) | 0.0004 | 134 (45.0) | 164 (55.0) | 0.81 | 19 (6.4) | 279 (93.6) | 0.0008 |
<14 | 180 | 42 (23.3) | 138 (66.7) | 83 (46.1) | 97 (53.4) | 29 (16.1) | 151 (83.9) | |||
Relapse | ||||||||||
Yes | 71 | 17 (23.9) | 54 (76.1) | 0.048 | 40 (56.3) | 31 (43.7) | 0.045 | 15 (21.1) | 56 (78.9) | 0.0022 |
No | 407 | 58 (14.3) | 349 (85.7) | 177 (43.5) | 230 (56.5) | 33 (8.1) | 374 (91.9) | |||