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Fig. 2 | Biomarker Research

Fig. 2

From: Advances in the DNA methylation hydroxylase TET1

Fig. 2

TET1-mediated active DNA demethylation. A complete model of TET1-mediated active DNA demethylation is shown. 5mC is formed by DNMT. TET1 gradually catalyze the oxidation of 5mC to form 5hmC, 5fC and 5caC. Among which 5hmC and 5caC can be eliminate the hydroxymethyl group and the carboxyl group to generate unmodified cytosine directly by DNMT, and 5hmC can also be catalyzed deamination by AID/APOBEC to 5hmU.5hmU along with 5fC and 5caC formed in the previous steps can be recognized and excised by TDG to generate an abasic site as part of the base excision repair (BER) process that regenerates unmodified C

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