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Fig. 1 | Biomarker Research

Fig. 1

From: Advances in the DNA methylation hydroxylase TET1

Fig. 1

TET1 prevents DNA from maintenance methylation. TET1 catalyzes initial DNA strand methylation site hydroxylation to 5hmC, which lead to the inability of UHRF1 binding to the daughter strand and DNMT1 catalyzing 5C to 5mC. Thereby preventing the maintenance of DNA methylation and thus passively eliminating 5mC by replication

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Biomarker Research

ISSN: 2050-7771

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