Deciphering genes associated with diffuse large B-cell lymphoma with lymphomatous effusions: A mutational accumulation scoring approach

Table 1 Clinicopathologic features of DLBCL patients with lymphomatous effusions for NGS study

Case	Age	Sex	Subtype COO	Genetic	BCL2	Ki-67	c-MYC	Stage	Status
S9	56	M	ABC	EZB	+	60–70 %	+	IIIE	Alive
S10	69	M	ABC	MCD	-	60–70 %	+	IIIE	Dead
S11	71	M	ABC	EZB	+	> 90 %	+	IV	Dead
S12	52	F	GCB	EZB	-	50–60 %	-	IV	Alive
S13	45	M	GCB	N1	-	> 90 %	+	IIE	Alive
S14	39	M	GCB	BN2	+	70–80 %	-	IV	Alive
S15	63	F	GCB	UN	+	70–80 %	-	IIIE	Dead
S16	83	M	GCB	BN2	+	80–90 %	+	IVE	Dead
S17	85	F	ABC	MCD	+	> 90 %	-	IE	Dead

Abbreviations: +, positive; -, negative; Subtype of ABC (activated B-cell) or GCB (germinal center B-cell) determined by Hans cell-of-origin (COO) classification [15]. Genetic subtype based on MCD (MYD88 and CD79B mutations), BN2 (BCL6 fusion and NOTCH2 mutation), N1 (NOTCH1 mutation), and EZB (EZH2 mutation and BCL2 translocation) [6]. All 9 cases had lymphomatous effusions and were negative for Epstein-Barr virus (EBV); Stage, Ann-Arbor staging system

ISSN: 2050-7771