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Table 1 Clinicopathologic features of DLBCL patients with lymphomatous effusions for NGS study

From: Deciphering genes associated with diffuse large B-cell lymphoma with lymphomatous effusions: A mutational accumulation scoring approach

Case Age Sex Subtype
COO
Genetic BCL2 Ki-67 c-MYC Stage Status
S9 56 M ABC EZB + 60–70 % + IIIE Alive
S10 69 M ABC MCD - 60–70 % + IIIE Dead
S11 71 M ABC EZB + > 90 % + IV Dead
S12 52 F GCB EZB - 50–60 % - IV Alive
S13 45 M GCB N1 - > 90 % + IIE Alive
S14 39 M GCB BN2 + 70–80 % - IV Alive
S15 63 F GCB UN + 70–80 % - IIIE Dead
S16 83 M GCB BN2 + 80–90 % + IVE Dead
S17 85 F ABC MCD + > 90 % - IE Dead
  1. Abbreviations: +, positive; -, negative; Subtype of ABC (activated B-cell) or GCB (germinal center B-cell) determined by Hans cell-of-origin (COO) classification [15]. Genetic subtype based on MCD (MYD88 and CD79B mutations), BN2 (BCL6 fusion and NOTCH2 mutation), N1 (NOTCH1 mutation), and EZB (EZH2 mutation and BCL2 translocation) [6]. All 9 cases had lymphomatous effusions and were negative for Epstein-Barr virus (EBV); Stage, Ann-Arbor staging system