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Fig. 6 | Biomarker Research

Fig. 6

From: Deciphering genes associated with diffuse large B-cell lymphoma with lymphomatous effusions: A mutational accumulation scoring approach

Fig. 6

Validation of PDIA4, TP53BP2, HDAC1 and MDM2 protein levels in DLBCL cell lines and clinical samples. The protein level of PDIA4, TP53BP2 was evaluated (A) in various DLBCL cell lines and (B) clinical specimens by western blot (LCL cells as control). (C, D) Representative IHC staining of HDAC1 and MDM2 in an independent cohort of 51 DLBCL cases with (n = 31) and without (n = 20) lymphomatous effusions, respectively. Scale bars denote 50 μm. (E) The positive correlation between lymphomatous effusions and HDAC1 and MDM2 expression. (F) Kaplan-Meier survival analysis to compare the cumulative survival rate of all patients with various HDAC1 expression levels

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