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Table 6 Area under the receiver operator curve (AUROC) for biomarker studies predicting outcome from mTBI

From: Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues

Marker Study Year N Time (hrs) AUROC Outcome
       Predicted
GFAP Huebschmann [109] 2020 121 0-12 0.69 GOS-E >6
  Pattinson [124] 2020 59 0-12 0.40 RTS <8 days
NF-L Shahim [72] 2018 87 0-1 0.83 RTS <15 days
  Shahim [84] 2017 35 0-1 0.82 RTS <6 days
S100B Shahim [85] 2014 28 0-1 0.68 Duration of PCS <6 days
  Babcock [125] 2008 76 0-6 0.47 Onset of PCS
tau-A Shahim [67] 2016 28 0-1 0.87 RTS <10 days
tau-C Shahim [67] 2016 28 0-1 0.58 RTS <10 days
tau-T Shahim [85] 2014 28 0-1 0.91 Duration of PCS <6 days
  Gill [87] 2017 43 0-6 0.81 RTS <10 days
  Pattinson [124] 2020 59 Recovered 0.75 RTS <8 days
  Shahim [72] 2018 87 0-1 0.67 RTS <15 days
  Pattinson [124] 2020 55 24-48 0.66 RTS <8 days
  Hossain [126] 2020 105 0-24 0.56 GOS-E >7
  1. RTS Return to sport.
  2. bolded AUROC values ≥0.80