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Table 6 Area under the receiver operator curve (AUROC) for biomarker studies predicting outcome from mTBI

From: Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues

Marker

Study

Year

N

Time (hrs)

AUROC

Outcome

      

Predicted

GFAP

Huebschmann [109]

2020

121

0-12

0.69

GOS-E >6

 

Pattinson [124]

2020

59

0-12

0.40

RTS <8 days

NF-L

Shahim [72]

2018

87

0-1

0.83

RTS <15 days

 

Shahim [84]

2017

35

0-1

0.82

RTS <6 days

S100B

Shahim [85]

2014

28

0-1

0.68

Duration of PCS <6 days

 

Babcock [125]

2008

76

0-6

0.47

Onset of PCS

tau-A

Shahim [67]

2016

28

0-1

0.87

RTS <10 days

tau-C

Shahim [67]

2016

28

0-1

0.58

RTS <10 days

tau-T

Shahim [85]

2014

28

0-1

0.91

Duration of PCS <6 days

 

Gill [87]

2017

43

0-6

0.81

RTS <10 days

 

Pattinson [124]

2020

59

Recovered

0.75

RTS <8 days

 

Shahim [72]

2018

87

0-1

0.67

RTS <15 days

 

Pattinson [124]

2020

55

24-48

0.66

RTS <8 days

 

Hossain [126]

2020

105

0-24

0.56

GOS-E >7

  1. RTS Return to sport.
  2. bolded AUROC values ≥0.80