Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues

Biomarker Research

Table 5 Area under the receiver operator curve (AUROC) for CT positivity by biomarker

Marker	Study	Year	Study Size	Sampling	AUROC
	Lead Author		(N)	Time (hrs)
GFAP	Czeiter [108]	2020	2867‡	0-24	0.89
	Gardner [94]	2018	169	0-24	0.88
	Huebschmann [109]	2020	121	0-12	0.81
	Welch [65]	2016	251	0-6	0.78
	Gill [71]	2018	277	0-48	0.77
	Yue [82]∗	2019	450	0-24	0.77
	Lewis [103]	2017	188	0-6	0.66
NF-L	Gill [71]	2018	277	0-48	0.65
S100B	Welch [65]	2016	251	0-6	0.75
	Allouchery [110]	2018	1449	0-2	0.72
	Jones [111]	2020	679	0-6	0.69
	Egea-Guerrero [112]	2018	260	0-6	0.67
	Lewis [103]	2017	188	0-6	0.65
	Yue [82]∗	2019	450	0-24	0.56
tau-P	Gardner [94]	2018	169	0-24	0.93
tau-T	Gardner [94]	2018	169	0-24	0.71
	Diaz-Arrastia [113]	2014	171	0-24	0.67
	Gill [71]	2018	277	0-48	0.66
UCH-L1	Welch [65]	2016	251	0-6	0.79
	Lewis [103]	2017	188	0-6	0.60
	Yue [82]∗	2019	450	0-24	0.59

The bolded AUROC values are ≥0.80
^∗This study compared MR- vs. MRI+ in CT- subjects. All other studies are CT- vs. CT+.
^†1951 of 2867 subjects had mTBI.
^‡Concussed male football players only, females excluded.

ISSN: 2050-7771