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Table 5 Area under the receiver operator curve (AUROC) for CT positivity by biomarker

From: Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues

Marker Study Year Study Size Sampling AUROC
  Lead Author   (N) Time (hrs)  
GFAP Czeiter [108] 2020 2867‡ 0-24 0.89
  Gardner [94] 2018 169 0-24 0.88
  Huebschmann [109] 2020 121 0-12 0.81
  Welch [65] 2016 251 0-6 0.78
  Gill [71] 2018 277 0-48 0.77
  Yue [82] 2019 450 0-24 0.77
  Lewis [103] 2017 188 0-6 0.66
NF-L Gill [71] 2018 277 0-48 0.65
S100B Welch [65] 2016 251 0-6 0.75
  Allouchery [110] 2018 1449 0-2 0.72
  Jones [111] 2020 679 0-6 0.69
  Egea-Guerrero [112] 2018 260 0-6 0.67
  Lewis [103] 2017 188 0-6 0.65
  Yue [82] 2019 450 0-24 0.56
tau-P Gardner [94] 2018 169 0-24 0.93
tau-T Gardner [94] 2018 169 0-24 0.71
  Diaz-Arrastia [113] 2014 171 0-24 0.67
  Gill [71] 2018 277 0-48 0.66
UCH-L1 Welch [65] 2016 251 0-6 0.79
  Lewis [103] 2017 188 0-6 0.60
  Yue [82] 2019 450 0-24 0.59
  1. The bolded AUROC values are ≥0.80
  2. This study compared MR- vs. MRI+ in CT- subjects. All other studies are CT- vs. CT+.
  3. 1951 of 2867 subjects had mTBI.
  4. Concussed male football players only, females excluded.