Table 7 Univariable and multivariable survival analysis for PFS using Cox proportional hazards models
Group | Immune Biomarker | Univariable | Multivariable | ||
|---|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | ||
Cohort A | ALCs > = 800 < 800 | 5.08 (1.62, 15.92) | 0.005 | 4.25 (1.21, 14.87) | 0.024 |
CD4 plus CD8 counts > = 500 < 500 | 6.36 (1.76, 22.97) | 0.005 | 8.89 (1.89, 41.86) | 0.006 | |
PD-L1 IHC > = 50% < 50% | 1.17 (0.42, 3.30) | 0.764 | – | – | |
TMB > = 10 < 10 | 0.99 (0.13, 7.66) | 0.989 | – | – | |
Cohort B | ALCs > = 800 < 800 | 2.63 (1.16, 5.99) | 0.021 | 2.50 (1.05, 5.95) | 0.038 |
CD4 plus CD8 counts > = 500 < 500 | 2.70 (1.21, 6.04) | 0.016 | 2.94 (1.18, 7.37) | 0.021 | |
PD-L1 IHC > = 50% < 50% | 2.36 (1.04, 5.37) | 0.040 | 5.21 (1.77, 15.38) | 0.003 | |
TMB > = 10 < 10 | 3.16 (1.27, 7.86) | 0.013 | 4.11 (1.58, 10.70) | 0.004 | |