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Table 4 Comparisons of baseline/post/change between good vs poor responders in Cohort A

From: Small molecule tyrosine kinase inhibitors modulated blood immune cell counts in patients with oncogene-driven NSCLC

Response Good Response Poor Response Difference (Good - Poor)
Timepoints Baseline Post-treatment Change (Post - Pre) Baseline Post-treatment Change (Post - Pre) Baseline Post-treatment Change
Blood biomarker Mean (±SD) Mean (±SD) Mean (±SD) Mean (±SD) Mean (±SD) Mean (±SD) Mean (±SE) P-value$ Mean (±SE) P-value$ Mean (±SE) P-value$
WBC (×103 cells/μL) 9.2 (±3.7) 6.3 (±2.3) −2.9 (±3.1) 7.2 (±3.4) 7.9 (±3.5) 0.6 (±2.6) 1.9 (±1.4) 0.092 − 1.6 (±1.1) 0.309 −3.5 (±1.1) 0.015
Hemoglobulin (gram/dL) 12.6 (±2.2) 12.6 (±1.8) 0.0 (±1.8) 12.2 (±1.7) 11.8 (±1.8) −0.4 (±0.8) 0.4 (±0.8) 0.480 0.8 (±0.7) 0.210 0.3 (±0.6) 0.807
Platelet count (×103 cells/μL) 339.9 (±121.6) 248.7 (±96.1) −91.3 (±103.8) 254.7 (±121.5) 234.5 (±96.5) −20.2 (±95.9) 85.2 (±47.6) 0.092 14.1 (±37.7) 0.643 −71.1 (±39.5) 0.079
ANC (×103 cells/μL) 6.8 (±3.6) 4.4 (±2.3) −2.5 (±3.2) 5.1 (±3.0) 6.2 (±3.3) 1.1 (±2.5) 1.7 (±1.3) 0.237 −1.9 (±1.1) 0.095 −3.6 (±1.1) 0.014
ALCs (×103 cells/μL) 1.4 (±0.7) 1.2 (±0.7) −0.2 (±0.7) 1.2 (±0.9) 0.9 (±0.4) −0.4 (±0.5) 0.2 (±0.3) 0.395 0.4 (±0.2) 0.078 0.2 (±0.3) 0.575
CD3 + CD4 + % 38.7 (±10.9) 39.4 (±8.8) 0.7 (±8.0) 43.3 (±11.2) 39.0 (±9.0) −4.3 (±4.5) −4.6 (±4.3) 0.276 0.4 (±3.5) 0.922 5.0 (±2.7) 0.100
CD3 + CD8 + % 23.9 (±9.3) 24.8 (±7.8) 0.9 (±3.9) 23.8 (±10.4) 23.2 (±10.9) −0.6 (±2.2) 0.1 (±3.8) 0.806 1.6 (±3.6) 0.436 1.5 (±1.3) 0.234
CD3 + % 64.3 (±9.0) 66.0 (±8.0) 1.7 (±7.0) 67.8 (±12.0) 63.1 (±10.0) −4.7 (±5.5) −3.5 (±4.0) 0.357 2.9 (±3.5) 0.355 6.4 (±2.5) 0.041
CD3 + CD4+ count (cells/μL) 541.4 (±311.1) 466.3 (±213.0) −75.1 (±314.4) 471.5 (±244.6) 344.9 (±179.5) −126.5 (±94.8) 69.9 (±112.1) 0.592 121.4 (±78.4) 0.157 51.5 (±98.2) 0.592
CD3 + CD8+ count (cells/μL) 372.3 (±296.3) 307.7 (±232.8) −64.6 (±234.0) 239.9 (±97.6) 184.1 (±88.6) −55.8 (±30.2) 132.3 (±93.1) 0.321 123.6 (±74.0) 0.041 −8.7 (±71.4) 0.714
CD4/CD8 ratio 1.9 (±0.8) 1.8 (±0.8) −0.1 (±0.6) 2.1 (±1.0) 2.1 (±1.2) 0.0 (±0.5) −0.3 (±0.3) 0.527 −0.3 (±0.4) 0.527 −0.1 (±0.2) 0.788
CD4 plus CD8 count (cells/μL) 913.6 (±524.8) 774.0 (±407.0) −139.6 (±507.4) 711.4 (±301.2) 529.0 (±227.2) − 182.4 (±119.1) 202.3 (±175.8) 0.321 245.0 (±135.7) 0.039 42.7 (±156.7) 0.643
dNLR 3.8 (±3.8) 2.6 (±1.8) −1.2 (±3.8) 2.8 (±1.0) 4.0 (±2.0) 1.2 (±1.6) 1.00 (±1.2) 0.575 −1.4 (±0.7) 0.033 −2.4 (±1.2) 0.027
  1. Abbreviation: SD Standard Deviation, SE Standard Error
  2. $P-values from Wilcoxon rank sum tests. Bold for statistical significance