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Fig. 5 | Biomarker Research

Fig. 5

From: Small molecule tyrosine kinase inhibitors modulated blood immune cell counts in patients with oncogene-driven NSCLC

Fig. 5

Kaplan-Meier PFS and OS estimates according to ALCs, CD4 plus CD8 counts, PD-L1 IHC and TMB in cohort A. Post-treatment low ALCs (< 800 cells/μL, red) were associated with shorter PFS and OS compared to high ALCs (≥800 cells/μL, blue) in patients with oncogene-driven NSCLC (cohort A) (A and B), respectively. Post-treatment low CD4 plus CD8 cell counts (< 500 cells/μL, red) were associated with shorter PFS and OS compared to high CD4 plus CD8 cell counts (≥500 cells/μL, blue) (cohort A) (A and B), respectively. PD-L1 IHC expression (C) and TMB status (D) did not affect the PFS and OS in NSCLC patients with oncogene driven NSCLC. Tick marks indicate censored data. Groups were compared using the log-rank test. P < 0.05 for statistical significance

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