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Table 3 Potential molecules and targets in drug development

From: The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy

Molecules Targets Inhibitor/activator of the target Effect on signaling Test in cancer References
LGK974 Porcupine inhibitor inhibits head and neck cancer, breast cancer, cervical cancer [66]
IWP Porcupine inhibitor inhibits colorectal cancer [67]
C59 Porcupine inhibitor inhibits breast cancer [68]
ETC-159 Porcupine inhibitor inhibits colorectal cancer [69]
OMP-18R5 Frizzled inhibitor inhibits breast cancer, pancreatic cancer, colon cancer, lung cancer [70]
OMP-54F28 Frizzled inhibitor inhibits breast cancer, pancreatic cancer [71]
Niclosamide Frizzled 1 inhibitor inhibits osteosarcoma [72]
Peptide dFz7–21 Frizzled 7 inhibitor inhibits not test [73]
RK-582 Tankyrase, AXIN activates AXIN inhibits colorectal cancer [74]
XAV939 Tankyrase, AXIN activates AXIN inhibits colorectal cancer [75]
G007-LK Tankyrase, AXIN activates AXIN inhibits colorectal cancer [76]
RK-287107 Tankyrase, AXIN activates AXIN inhibits colorectal cancer [77]
JW55 Tankyrase 1, tankyrase 2 activates AXIN inhibits colon cancer [78]
IWR Tankyrase, AXIN activates AXIN inhibits colorectal cancer, cervical cancer [79]
Shizokaol D beta-catenin inhibitor inhibits liver Cancer [80]
NCB-0846 Traf2- and Nck-interacting kinase (TNIK) inhibitor inhibits colorectal cancer [81]
LF3 beta-catenin / TCF4 inhibitor inhibits colon cancer [82]
2,4-diamino-quinazoline beta-catenin / TCF4 inhibitor inhibits colorectal cancer [83]
PKF115–584, CGP049090 beta-catenin inhibitor inhibits colon cancer [84]
BC21 TCF/beta-catenin inhibitor inhibits colon cancer [85]
Sulindac TCF/beta-catenin inhibitor inhibits familial adenomatous polyposis, colorectal cancer [86]
NSC668036 PDZ domain of Dvl inhibitor inhibits not test [87]
3289–8625 PDZ domain of Dvl inhibitor inhibits prostate cancer [88]
BC2059 beta-catenin/ transducin β-like 1 inhibitor inhibits acute myeloid leukemia [89]
Ant1.4Br/Ant 1.4Cl Wnt3a inhibitor inhibits not test [90]
Pyrvinium CK1α activator inhibits colon cancer [91]
Quercetin beta-catenin / TCF4 inhibitor inhibits colon cancer [85, 92]
ICG-001 cyclic AMP response element-binding protein (CBP) inhibitor inhibits colon cancer [93]
Apicularen and bafilomycin Vacuolar H + -ATPase inhibitor inhibits teratocarcinoma, neuroblastoma [94]
Gugulipid TCF-4 inhibitor inhibits breast cancer [95]