Table 3 Potential molecules and targets in drug development

LGK974

Porcupine

inhibitor

inhibits

head and neck cancer, breast cancer, cervical cancer

[66]

IWP

Porcupine

inhibitor

inhibits

colorectal cancer

[67]

C59

Porcupine

inhibitor

inhibits

breast cancer

[68]

ETC-159

Porcupine

inhibitor

inhibits

colorectal cancer

[69]

OMP-18R5

Frizzled

inhibitor

inhibits

breast cancer, pancreatic cancer, colon cancer, lung cancer

[70]

OMP-54F28

Frizzled

inhibitor

inhibits

breast cancer, pancreatic cancer

[71]

Niclosamide

Frizzled 1

inhibitor

inhibits

osteosarcoma

[72]

Peptide dFz7–21

Frizzled 7

inhibitor

inhibits

not test

[73]

RK-582

Tankyrase, AXIN

activates AXIN

inhibits

colorectal cancer

[74]

XAV939

Tankyrase, AXIN

activates AXIN

inhibits

colorectal cancer

[75]

G007-LK

Tankyrase, AXIN

activates AXIN

inhibits

colorectal cancer

[76]

RK-287107

Tankyrase, AXIN

activates AXIN

inhibits

colorectal cancer

[77]

JW55

Tankyrase 1, tankyrase 2

activates AXIN

inhibits

colon cancer

[78]

IWR

Tankyrase, AXIN

activates AXIN

inhibits

colorectal cancer, cervical cancer

[79]

Shizokaol D

beta-catenin

inhibitor

inhibits

liver Cancer

[80]

NCB-0846

Traf2- and Nck-interacting kinase (TNIK)

inhibitor

inhibits

colorectal cancer

[81]

LF3

beta-catenin / TCF4

inhibitor

inhibits

colon cancer

[82]

2,4-diamino-quinazoline

beta-catenin / TCF4

inhibitor

inhibits

colorectal cancer

[83]

PKF115–584, CGP049090

beta-catenin

inhibitor

inhibits

colon cancer

[84]

BC21

TCF/beta-catenin

inhibitor

inhibits

colon cancer

[85]

Sulindac

TCF/beta-catenin

inhibitor

inhibits

familial adenomatous polyposis, colorectal cancer

[86]

NSC668036

PDZ domain of Dvl

inhibitor

inhibits

not test

[87]

3289–8625

PDZ domain of Dvl

inhibitor

inhibits

prostate cancer

[88]

BC2059

beta-catenin/ transducin β-like 1

inhibitor

inhibits

acute myeloid leukemia

[89]

Ant1.4Br/Ant 1.4Cl

Wnt3a

inhibitor

inhibits

not test

[90]

Pyrvinium

CK1α

activator

inhibits

colon cancer

[91]

Quercetin

beta-catenin / TCF4

inhibitor

inhibits

colon cancer

[85, 92]

ICG-001

cyclic AMP response element-binding protein (CBP)

inhibitor

inhibits

colon cancer

[93]

Apicularen and bafilomycin

Vacuolar H + -ATPase

inhibitor

inhibits

teratocarcinoma, neuroblastoma

[94]

Gugulipid

TCF-4

inhibitor

inhibits

breast cancer

[95]