Skip to main content

Table 1 Summary of OVs against TNBC

From: Oncolytic viruses for triple negative breast cancer and beyond

Virus Receptor Vector Modification Mechanism Ref
Adenovirus Coxsackie and adenovirus receptor (CAR), CD46, Desmoglein-2(DSG-2) CNHK600-IL24 Arm with IL-24 Induce TNBC apoptosis [41]
p55-hTERT-HRE-TRAIL Arm with P55-HTERT-HRE-TRAIL Target TNBC and induce apoptosis [42]
OBP-401 adenovirus Arm with the human telomerase reverse transcriptase (hTERT) gene Increase the targeting to cancer cells [43]
Ad5-10miR145T Carry ten miR-145-5p target sequences Target miR-145-5P [44]
Ad.DCN Express decorin protein Promote the expression of decorin [45]
SG400-E2F/IL-15 Replace the endogenous promoter with the E2F-1 promoter and arm with IL-15 gene Target E2F and promote the expression of IL-15 [46]
Herpes simplex virus Herpes virus entry mediator (HVEM), nectin1/2, heparan sulfate proteoglycans (HSPG) G47Δ Delete α47 and γ34.5 genes; Insert Escherichia Coli LacZ into ICP6 Enhance cytotoxicity to tumor cells [47, 48]
GD116 Insert MyD116 C-terminus Enhance the replication and virulence [49]
G47Δ-mIL12 Insert IL-12 into G47Δ Enhance antitumor immune response [50]
Vaccinia virus Glycosaminoglycans/ laminin, macrophage receptor with collagenous structure (MARCO) VV40L Arm with CD40 ligand Target CD40 [51]
VG9-IL-24 Arm with IL-25 Induce apoptosis [52]
Reovirus Carbohydrates, Junction adhesion molecule-A(JAM-A) reo-dox Conjugate Doxorubicin Enhance cytotoxicity [53]
Vesicular Stomatitis Virus Low-density lipoprotein (LDLR) VSVd51 A mutation in the matrix protein Expands the tropism for diverse cancer types [54]
Measles virus CD46, nectin-4 rMV-SLAMblind Mutate R533A in the H protein Entry cancer cells through nectin-4 receptor [55]
rMV-BNiP3 Arm with BNiP3 Enhance the ability of Inducing apoptosis [56]
Newcastle disease virus Sialic acid (SA) rAF-IL12 Insert IL-12 Enhance anti-tumor immune response [57]
Maraba virus Low-density lipoprotein receptor (LDLR) MG1 Mutate G protein (Q242R) and M protein (L123W) Improve virulence and reduce the ability to kill normal cells [58, 59]
Coxsackievirus Coxsackie and adenovirus receptor(CAR), Intracellular adhesion molecule-1(ICAM-1) CVA21 Natural strain Capable of lytic infection of breast cancer cells [60]