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Table 2 Summary of the discussed CAR-T for solid tumors

From: Novel strategies for immuno-oncology breakthroughs with cell therapy

Presenter

Target

Co-stimulatory molecule

Tumor type

Registration Number

Prasad Adusumilli

Mesothelin

CD28

Mesothelioma

TNBC

NCT02414269

Mesothelin

CD28 with PD-1 dominant negative receptor

Mesothelioma

NCT04577326

Marcela Maus

EGFRvIII

4-1BB

Glioblastoma

NCT02209376

Stanley Riddell

ROR1

4-1BB

ROR1 positive:

Lung cancer

TNBC

Hematologic malignancies

NCT02706392