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Table 1 Tumor antigen summary

From: Targeting neoantigens for cancer immunotherapy

Category Tumor-associated antigens (TAAs) Oncogenic virus-derived antigens Tumor-specific antigens (TSAs, neoantigens)
Expression site Mostly restricted to tumors, sometimes expressed in normal tissue Infected cells and virus-related tumor cells Restricted to tumors
Origin Abnormal gene expression Virus infection Mutated peptides derived from genomic alterations
Subset Overexpressed proteins Differentiation antigens Cancer/testis antigens N/A Public neoantigens Private neoantigens
Specificity Variable Variable Good Ideal Ideal
Central tolerance High High Low None None
Prevalence across multiple cancers High High High in certain cancers High in certain cancers High Low