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Table 1 Clinical features of B-ALL pediatric patients enrolled for the analysis of TEX41 expression

From: The lncRNA TEX41 is upregulated in pediatric B-Cells Acute Lymphoblastic Leukemia and it is necessary for leukemic cell growth

PATIENT ID

Pt 1

Pt 2

Pt 3

Pt 4

Pt 5

Pt 6

Pt 7

Pt 8

Pt 9

Pt 10

Age (years)

3,6

4,5

2,9

11,1

10,9

15

10,2

9,9

14,8

4.9

Sex

M

M

F

M

F

F

M

F

M

M

Race

Caucasian

Caucasian

Caucasian

Caucasian

Caucasian

Caucasian

Indian

Caucasian

Caucasian

Caucasian

WBC

67,550/mmc

n.d.

n.d.

3790/mmc

4730/mmc

  

120,690/mmc

453,600/mmc

 

BM blast(%)

68

80

70

65

89

50

80

90

95

70

Immuno-phenotype

B common

B common

B common

B common

B common

B common

B common

B common

B common

B common

Molecular biology

t (1;19)

E2A/PBX1 rearrangement

t (12;21)

TEL/AML1 rearrangement

Negative

Negative

Negative

Negative

Negative

Negative

Negative

t (12;21)

TEL/AML1 rearrangement

Cytogenetic

45, XY, i (9)(q10), -13, add (19)(p13)[8]/46, XY,[8]

46,XY

46,XX

59, XXXY, + 4,+4,+5,+6, + 10 + 14,+17,18,+21,+21[5]/46, XY, [10]

NE

46, XX

NE

NE

46, XY

46, XY

GPR day + 8

Yes

Yes

Yes

Yes

Yes

Yes

Yes

No

Yes

Yes

BM blast < 10 % day + 15

Yes

Yes

Yes

Yes

Yes

Yes

Yes

No

Yes

Yes

NCI risk

High

NE

High

High

High

High

High

High

High

High

MRD risk

Standard

Intermediate

Intermediate

Standard

Intermediate

NE

NE

NE

NE

NE

Tex41

0,00048571

0,00003693

0,00004515

0,00120526

0,00001881

0,00003052

0,00001824

0,00001256

0,00001052

0,00107202

  1. WBC white blood count; BM bone marrow blast; GPR good prednisone responder; NCI national cancer institute; MRD minimal residual disease; NE not evaluable (absence of metaphases)