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Table 4 Response Assessment in Neuro-Oncology (RANO) Criteria

From: Imaging biomarkers for evaluating tumor response: RECIST and beyond

Criterion

CR

PR

SD

PD

T1WI with CE

None

≥ 50 %↓

˂ 50 %↓but ˂ 25 %↑

≥ 25 %↑a

T2WI/FLAIR

Stable or ↓

Stable or ↓

Stable or ↓

↑a

New lesion

None

None

None

Presenta

Corticosteroid

None

Stable or ↓

Stable or ↓

N/Ab

Clinical Status

Stable or ↑

Stable or ↑

Stable or ↑

↓a

Response Requirement

All

All

All

Anya

  1. CE contrast enhancement, CR complete response, FLAIR fluid attenuated inversion recovery, PD progressive disease, PR partial response, SD stable disease, T1WI T1-weighted MR imaging, T2WI T2-weighted MR imaging
  2. aProgression occurs when any this criterion is present
  3. bN/A not applicable