Fig. 6

Comparison between RECIST and Lee’s criteria in NSCLC. A 51-year-old man was diagnosed with NSCLC. A Pretreatment CE axial CT scan in lung window shows a 92-mm-sized tumor, including both solid and GGO components (black arrows). B After targeted therapy with afatinib, posttreatment CE CT scan shows no significant decrease in tumor size (84 mm in diameter, 9 % reduction) (black arrows), suggesting stable disease according to RECIST 1.1. C According to Lee’s criteria, the size of the target lesion (white arrows) is measured on pretreatment CE axial CT by solid component alone (79 mm in diameter) on soft tissue window imaging. D After targeted therapy, the size of the target lesion is measured by including only soft-tissue tumor (white arrows) (77 mm in diameter) and excluding necrotic air cavitation (asterisk) (49 mm in diameter), thus the tumor size is 28mm (65 % reduction), suggesting good tumor response according to Lee’s criteria