Fig. 1
Leukemic-transformation time (LTT) curves. A LTT for all patients. Median LTT: 71.5 for MDS; 31.9 months for MDS-MF1; 5.6 months for MDS-MF2 − 3; MDS-MF2 − 3 vs. MDS p < 0.001; MDS-MF1 vs. MDS p = 0.045; MDS-MF2 − 3 vs. MDS-MF1p = 0.001. B LTT according to International Prognostic Scoring System (IPSS) risk categories. In the IPSS low/int-1 risk groups, median LTT: 71.5 months for MDS; 40.4 months for MDS-MF1; 2.8 months for MDS-MF2 − 3; MDS vs. MDS-MF1p = 0.029; MDS vs. MDS-MF2 − 3p < 0.001; MDS-MF2 − 3 vs. MDS-MF1p = 0.001. In the IPSS int-2/high risk groups, median LTT: 27.2 months for MDS; 17.8 months for MDS-MF1; 5.6 months for MDS-MF2 − 3; MDS vs. MDS-MF1p = 0.323; MDS vs. MDS-MF2 − 3p = 0.024; MDS-MF2 − 3 vs. MDS-MF1p = 0.131. Five Patients with IPSS int-2/high risk who refused chemotherapy; seven patients who received allogeneic-hematopoietic stem cell transplantation (4 MDS; 3 MDS-MF1) were excluded from LTT analysis. Two-tailed p-value < 0.05 by log-rank test was considered statistically significant. ^Another five patients who did not have cytogenetic analysis results (1 MDS; 3 MDS-MF1; 1 MDS-MF2 − 3) were excluded from IPSS-based LTT analysis